Aggregation of calcium ionophore (A23187) in phospholipid vesicles

The circular dichroism studies on calcium ionophore, A23187, incorporated in Dipalmitoyl phosphatidyl choline (DPPC) vesicle showed interesting time dependent changes in the CD spectra. Analysis of the data indicated the possible aggregation of the observed dimeric structure of this molecule in non-...

Full description

Saved in:
Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 158; no. 3; pp. 891 - 897
Main Authors Balasubramanian, S.V., Easwaran, K.R.K.
Format Journal Article
LanguageEnglish
Published San Diego, CA Elsevier Inc 15.02.1989
Elsevier
Subjects
1,2-Dipalmitoylphosphatidylcholine
Artificial membranes and reconstituted systems
Biological and medical sciences
Calcimycin
Circular Dichroism
Fundamental and applied biological sciences. Psychology
Kinetics
Liposomes
Macromolecular Substances
Membrane physicochemistry
Molecular biophysics
Molecular Structure
Aggregation
Calcium
Molecular structure
Apolar solvent
Circular dichroism spectrometry
Phospholipid
Lipids
Artificial membrane
Models
Time response relation
Ionophore
Dose activity relation
Online AccessGet full text

Cover

More Information
Summary:The circular dichroism studies on calcium ionophore, A23187, incorporated in Dipalmitoyl phosphatidyl choline (DPPC) vesicle showed interesting time dependent changes in the CD spectra. Analysis of the data indicated the possible aggregation of the observed dimeric structure of this molecule in non-polar solvents into a stacked dimeric pore in the phospholipid vesicle.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(89)92806-4