A 4.49nW/Pixel Light-to-Stimulus Duration Converter-Based Retinal Prosthesis Chip

This paper presents a 288-pixel retinal prosthesis (RP) chip implemented in a 0.18 μm CMOS process. The proposed light-to-stimulus duration converter (LSDC) and biphasic stimulator generate a wide range of retinal stimuli proportional to the incident light intensity at a low supply voltage of 1V. Th...

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Published inIEEE transactions on biomedical circuits and systems Vol. 15; no. 6; pp. 1140 - 1148
Main Authors Choi, Dong-Hwi, Roh, Hyeonhee, Im, Maesoon, Jee, Dong-Woo
Format Journal Article
LanguageEnglish
Published United States IEEE 01.12.2021
The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects
Animals
Brightness
CMOS process
CMOS sensor
Converters
Electric Stimulation
Electrical stimuli
Electrodes
implantable chip
Implants
Incident light
Light
Light intensity
light-to-stimulus duration converter
local return
low power
Low-power electronics
Luminous intensity
Mice
Photodiodes
Pixels
Power consumption
Prostheses
Prosthetics
Retina
Retina - physiology
Retinal ganglion cells
Retinal Ganglion Cells - physiology
retinal prostheses
Stimulators
Stimuli
Visual Prosthesis
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Abstract This paper presents a 288-pixel retinal prosthesis (RP) chip implemented in a 0.18 μm CMOS process. The proposed light-to-stimulus duration converter (LSDC) and biphasic stimulator generate a wide range of retinal stimuli proportional to the incident light intensity at a low supply voltage of 1V. The implemented chip shows 25.5 dB dynamic stimulation range and the state-of-the art low power consumption of 4.49 nW/pixel. Ex-vivo experiments were performed with a mouse retina and patch-clamp recording. The electrical artifact recorded by the patch electrode demonstrates that the proposed chip can generate electrical stimuli that have different pulse durations depending on the light intensity. Correspondingly, the spike counts in a retinal ganglion cell (RGC) were successfully modulated by the brightness of the light stimuli.
AbstractList This paper presents a 288-pixel retinal prosthesis (RP) chip implemented in a 0.18 μm CMOS process. The proposed light-to-stimulus duration converter (LSDC) and biphasic stimulator generate a wide range of retinal stimuli proportional to the incident light intensity at a low supply voltage of 1V. The implemented chip shows 25.5 dB dynamic stimulation range and the state-of-the art low power consumption of 4.49 nW/pixel. Ex-vivo experiments were performed with a mouse retina and patch-clamp recording. The electrical artifact recorded by the patch electrode demonstrates that the proposed chip can generate electrical stimuli that have different pulse durations depending on the light intensity. Correspondingly, the spike counts in a retinal ganglion cell (RGC) were successfully modulated by the brightness of the light stimuli.
Author Roh, Hyeonhee
Im, Maesoon
Jee, Dong-Woo
Choi, Dong-Hwi
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Snippet This paper presents a 288-pixel retinal prosthesis (RP) chip implemented in a 0.18 μm CMOS process. The proposed light-to-stimulus duration converter (LSDC)...
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SubjectTerms Animals
Brightness
CMOS process
CMOS sensor
Converters
Electric Stimulation
Electrical stimuli
Electrodes
implantable chip
Implants
Incident light
Light
Light intensity
light-to-stimulus duration converter
local return
low power
Low-power electronics
Luminous intensity
Mice
Photodiodes
Pixels
Power consumption
Prostheses
Prosthetics
Retina
Retina - physiology
Retinal ganglion cells
Retinal Ganglion Cells - physiology
retinal prostheses
Stimulators
Stimuli
Visual Prosthesis
Title A 4.49nW/Pixel Light-to-Stimulus Duration Converter-Based Retinal Prosthesis Chip
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https://www.ncbi.nlm.nih.gov/pubmed/34784285
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