Concentration-dependent respiratory response of guinea pigs to a single exposure of cotton dust

Eight groups of guinea pigs were exposed to cotton dust at concentrations of 2 to 27 mg/m3. Each exposure was for 6 hr. The pulmonary function of each animal was assessed prior to exposure, following exposure, and 18 hr following exposure. Tidal volume decreased while respiratory frequency increased...

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Bibliographic Details
Published inToxicology and applied pharmacology Vol. 80; no. 2; p. 357
Main Authors Ellakkani, M A, Alarie, Y C, Weyel, D A, Karol, M H
Format Journal Article
LanguageEnglish
Published United States 15.09.1985
Subjects
Animals
Atmosphere Exposure Chambers
Byssinosis - etiology
Dust
Gossypium - toxicity
Guinea Pigs
Male
Particle Size
Plethysmography, Whole Body
Respiration
Tidal Volume
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Summary:Eight groups of guinea pigs were exposed to cotton dust at concentrations of 2 to 27 mg/m3. Each exposure was for 6 hr. The pulmonary function of each animal was assessed prior to exposure, following exposure, and 18 hr following exposure. Tidal volume decreased while respiratory frequency increased in a concentration-dependent manner. These changes were amplified when the same measurements were conducted while the animals were breathing an atmosphere containing 10% CO2 in 19% O2 and 71% N2. Greatest response was noted at 18 hr postexposure. The concentration-response effects can be applied to evaluate the respiratory potencies of different cotton dusts grown under a variety of conditions.
ISSN:0041-008X
DOI:10.1016/0041-008X(85)90093-6