Attenuation of atherosclerotic complications by modulating inflammatory responses in hypercholesterolemic rats with dietary Njavara rice bran oil

• Published in: Biomedicine & pharmacotherapy Vol. 83; pp. 1387 - 1397
• Main Authors: Pushpan, Chithra K., MSc, V., Shalini, Ph.D, G., Sindhu, Ph.D, Rathnam, Parvathy, Ph.D, A., Jayalekshmy, A., Helen
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2016
• Subjects: Animals; Atherosclerosis; Atherosclerosis - diet therapy; Atherosclerosis - metabolism; Cells, Cultured; Endothelial cell; Hypercholesterolemia - diet therapy; Hypercholesterolemia - metabolism; Inflammation; Inflammation - diet therapy; Inflammation - metabolism; Inflammation Mediators - antagonists & inhibitors; Inflammation Mediators - metabolism; Internal Medicine; Macrophages; Male; Medical Education; Njavara rice bran oil; Plant Oils - isolation & purification; Plant Oils - pharmacology; Plant Oils - therapeutic use; Rats; Rats, Sprague-Dawley; Rice Bran Oil; interleukin-4; TNFα; interleukin-1; ICAM-1; cluster of differentiation 36; intercellular adhesion molecule 1; MPO; leukotriene E4; NF-κB; 15-LOX; CD36; 5-LOX; IFNγ; PBS; interferon gamma; IL-1; HCD; tolllike receptor 2; cyclooxygenase; tolllike receptor 4; IL-6; leukotriene C4; nuclear factor-κB; leukotriene D4; tumor necrosis factoralpha; NOS; LTE4; LTA4; TLR-2; NjRBO; lowdensity lipoprotein; TLR-4; MCP-1; Endothelial cell; monocyte chemoattractant protein-1; 15-lipoxygenase; Macrophages; nitric oxide synthases; LDL; Atherosclerosis; vascular cell adhesion molecule 1; LTD4; 5-lipoxygenase; peripheral blood mononuclear cells; myeloperoxidase; Inflammation; leukotriene A4; PBMCs; COX; Njavara rice bran oil; VCAM-1; phosphate buffered saline; LTC4; high cholesterol diet
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2016.08.001

Graphical abstract