Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard

Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might ne...

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Bibliographic Details
Published inJournal of clinical microbiology Vol. 55; no. 5; pp. 1262 - 1268
Main Authors Lockhart, Shawn R, Ghannoum, Mahmoud A, Alexander, Barbara D
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2017
Subjects
Antifungal Agents - pharmacology
Candida glabrata - drug effects
Candidiasis - drug therapy
Candidiasis - epidemiology
Cryptococcosis - drug therapy
Cryptococcosis - epidemiology
Cryptococcus neoformans - drug effects
Drug Resistance, Fungal - physiology
Humans
Microbial Sensitivity Tests - methods
Minireview
Treatment Outcome
epidemiological cutoff value
ECV
breakpoint
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Summary:Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.
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Citation Lockhart SR, Ghannoum MA, Alexander BD. 2017. Establishment and use of epidemiological cutoff values for molds and yeasts by use of the Clinical and Laboratory Standards Institute M57 standard. J Clin Microbiol 55:1262–1268. https://doi.org/10.1128/JCM.02416-16.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.02416-16