Bone marrow clastogenicity of trimethyltin

• Published in: Mutation Research Vol. 312; no. 1; pp. 9 - 15
• Main Author: Ganguly, Bani Bandana
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.1994; Elsevier
• Subjects: Administration, Oral; Analysis of Variance; Animals; Biological and medical sciences; Bone Marrow - drug effects; Bone Marrow Cells; Bone marrow chromosome; Chemical mutagenesis; Chromatids - drug effects; Chromosome Aberrations; Dose-Response Relationship, Drug; Male; Medical sciences; Mice; Micronucleus Tests; Mitosis - drug effects; Mitotic Index; Mutagens - toxicity; Toxicology; Trimethyltin; Trimethyltin Compounds - toxicity; D 1; T 1; D 0; D 3; T 3; Bone marrow chromosome; D 2; T 2; D 4; Trimethyltin; Vertebrata; Chromosome break; Intraperitoneal administration; Mammalia; Treatment; Mouse; Mutagenicity testing; Rodentia; Bone marrow; Tin Organic compounds
• ISSN: 0165-1161; 0027-5107
• DOI: 10.1016/0165-1161(94)90003-5

Aqueous solutions of trimethyltin in four different concentrations were administered i.p. for three different treatment periods, to five Swiss albino male mice for each experimental set. Bone marro cells were processed for somatic chromosomes preparation after 6, 18 and 24 h following the usual protocol. Structural abnormalities including chromatid and chromosomes breaks, dicentrics, rings and fragments were recorded. Critical assessment of the data with the one-tailed trend test revealed a significant positive trend of the dose effects in all three treatment periods. With the ANOVA test, significant variations in aberrations were observed between chemical concentrations and between treatment periods and their interaction (dose X time) was significant in aberrations and mitotic indices. Depression of mitotic index was dose- and duration-dependent.