Increase in micronucleated erythrocytes associated with babesiosis in Syrian golden hamsters

The effect of infection by Babesia microti, a tick-borne piroplasm endemic to the northeastern United States, on the temporal pattern of micronucleated erythrocyte frequencies in peripheral blood was investigated in male Syrian golden hamsters. Significantly greater frequencies of micronucleated ery...

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Bibliographic Details
Published inMutation research Vol. 227; no. 3; pp. 173 - 177
Main Authors Ormiston, Brian G., Luke, Carol A., Tice, Raymond R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.1989
Subjects
Animals
Babesiosis
Babesiosis - genetics
Cricetinae
Erythrocytes - ultrastructure
Male
Mesocricetus
Micronuclei
Micronucleus Tests
Reticulocytosis
Syrian hamster
Babesiosis
Syrian hamster
Micronuclei
Reticulocytosis
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Summary:The effect of infection by Babesia microti, a tick-borne piroplasm endemic to the northeastern United States, on the temporal pattern of micronucleated erythrocyte frequencies in peripheral blood was investigated in male Syrian golden hamsters. Significantly greater frequencies of micronucleated erythrocytes occurred in the blood of infected hamsters from 26 to 46 days after injection with B. microti, the magnitude of which within individual hamsters correlated highly with the percentage of polychromatic erythrocytes and the extent of parasitization. These data suggest that parasitic infection and other factors which alter the rate of erythropoiesis should be considered when the micronucleus assay is used in environmental or laboratory studies of genetic toxicity.
ISSN:0165-7992
0027-5107
DOI:10.1016/0165-7992(89)90042-0