Glutaraldehyde in whole-cell Bordetella pertussis vaccine

Treatment of the whole-cell bacterial suspensions of Bordetella pertussis with 0.05% glutaraldehyde at room temperature for 10 min kills the bacteria and, except for some histamine sensitising activity, almost detoxifies the pertussis toxin 1. The glutaraldehyde-vaccine is of good potency with a mer...

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Bibliographic Details
Published inVaccine Vol. 7; no. 6; p. 486
Main Authors Arya, S.C., Ashraf, S.J., Pathak, V.P.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.12.1989
Elsevier
Subjects
Action of physical and chemical agents on bacteria
Aldehydes - pharmacology
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Glutaral - analysis
Glutaral - pharmacology
Microbiology
Pertussis Vaccine - analysis
Pertussis Vaccine - toxicity
Chemical treatment
Purity
Bacteria
Detoxication
Vaccine
Bordetella pertussis
Inactivation
Recommendation
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Summary:Treatment of the whole-cell bacterial suspensions of Bordetella pertussis with 0.05% glutaraldehyde at room temperature for 10 min kills the bacteria and, except for some histamine sensitising activity, almost detoxifies the pertussis toxin 1. The glutaraldehyde-vaccine is of good potency with a meritorious performance in tests for abnormal toxicity in mice, the leucocytosis-promoting-factor and the mouse weight gain. Using glutaraldehyde for the inactivation of whole-cell pertussis vaccine on a commercial scale must await extensive clinical trials with vaccine lots with a good record of safety and potency in animal tests 1.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0264-410X
1873-2518
DOI:10.1016/0264-410X(89)90267-3