Cellular leiomyoma versus endometrial stromal sarcoma: A report of a rare case presenting a diagnostic challenge on intraoperative frozen section

Endometrial stromal sarcomas (ESSs) account for approximately 0.2% of all uterine malignancies. Cellular leiomyoma (CL) often simulates low-grade ESS due to similar cytology. We report the case of a 34-year-old female with a mass per abdomen. Frozen sections showed a tumor with many thin- and thick-...

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Published inGynecology and minimally invasive therapy Vol. 11; no. 3; pp. 182 - 184
Main Authors Agarwal, Charu, Pujani, Mukta, Chauhan, Varsha, Chawla, Raina, Agarwal, Anu, Menia, Reetika
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.07.2022
Medknow Publications and Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects
Case Report
cellular leiomyoma
Diagnosis
Endometrial cancer
endometrial stromal tumor
frozen section
Immunohistochemistry
Leiomyoma
Sarcoma
endometrial stromal tumor
immunohistochemistry
frozen section
Cellular leiomyoma
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Summary:Endometrial stromal sarcomas (ESSs) account for approximately 0.2% of all uterine malignancies. Cellular leiomyoma (CL) often simulates low-grade ESS due to similar cytology. We report the case of a 34-year-old female with a mass per abdomen. Frozen sections showed a tumor with many thin- and thick-walled vessels along with hyaline material. A differential diagnosis of CL and endometrial stromal tumor was suggested. The index case was diagnostically challenging to pathologists. Paraffin sections supplemented by immunohistochemistry (smooth muscle actin, CD10, and beta-catenin) favored CL. Frozen section sometimes leads to over/underestimation of tumor in view of small sampling area of tumor.
ISSN:2213-3070
2213-3089
DOI:10.4103/GMIT.GMIT_53_20