The developmental history of the gadolinium chelates as intravenous contrast media for magnetic resonance

The developmental history of the gadolinium chelates, which spans 30 years, is described, focusing, in part, on the seminal work with each of the major agents in use today. By examining this history, insight is gained into important issues of efficacy and safety, with valuable lessons to be learned...

Full description

Saved in:
Bibliographic Details
Published inInvestigative radiology Vol. 46; no. 12; p. 807
Main Authors Runge, Val M, Ai, Tao, Hao, Dapeng, Hu, Xuemei
Format Journal Article
LanguageEnglish
Published United States 01.12.2011
Subjects
Chelating Agents - chemistry
Contrast Media - chemistry
Gadolinium - chemistry
Humans
Injections, Intravenous
Magnetic Resonance Imaging
Online AccessGet more information

Cover

More Information
Summary:The developmental history of the gadolinium chelates, which spans 30 years, is described, focusing, in part, on the seminal work with each of the major agents in use today. By examining this history, insight is gained into important issues of efficacy and safety, with valuable lessons to be learned from the mistakes made during this period. An overview of physicochemical characteristics and chemical structures is also provided. The review concludes with a discussion of current research directions involving this field, which is that of the intravenous contrast media for magnetic resonance, in the past 5 years.
ISSN:1536-0210
DOI:10.1097/RLI.0b013e318237913b