Protein-protein interactions: mechanisms and modification by drugs
Protein–protein interactions form the proteinaceous network, which plays a central role in numerous processes in the cell. This review highlights the main structures, properties of contact surfaces, and forces involved in protein–protein interactions. The properties of protein contact surfaces depen...
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Published in | Journal of molecular recognition Vol. 15; no. 6; pp. 405 - 422 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.11.2002
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Subjects | |
Online Access | Get full text |
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Summary: | Protein–protein interactions form the proteinaceous network, which plays a central role in numerous processes in the cell. This review highlights the main structures, properties of contact surfaces, and forces involved in protein–protein interactions. The properties of protein contact surfaces depend on their functions. The characteristics of contact surfaces of short‐lived protein complexes share some similarities with the active sites of enzymes. The contact surfaces of permanent complexes resemble domain contacts or the protein core. It is reasonable to consider protein–protein complex formation as a continuation of protein folding. The contact surfaces of the protein complexes have unique structure and properties, so they represent prospective targets for a new generation of drugs. During the last decade, numerous investigations have been undertaken to find or design small molecules that block protein dimerization or protein(peptide)–receptor interaction, or on the other hand, induce protein dimerization. Copyright © 2002 John Wiley & Sons, Ltd. |
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Bibliography: | ark:/67375/WNG-D0KGH4DL-X RFBR - No. N 99-04-48081; No. N 01-04-48128 istex:B22D6D396F04FB64494626231B206EC63D6E4EDD ArticleID:JMR597 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0952-3499 1099-1352 |
DOI: | 10.1002/jmr.597 |