Nucleic Acid Studies in Experimental Cardiomegaly

1. A group of weanling rats was made anemic by an Fe- and Cu-deficient diet consisting of cowʼs milk. An appropriate control group receiving Fe and Cu in addition to milk was also studied. After 86–105 days, the rats were sacrificed; hematocrit levels, heart weights, DNA, RNA, and protein concentrat...

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Bibliographic Details
Published inCirculation research Vol. 12; no. 2; pp. 170 - 175
Main Authors Sumner, Robert G, Mcintosh, Henry D
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 01.02.1963
Subjects
Cardiomegaly
DNA
Nucleic Acids
Old Medline
RNA
RNA
HEART ENLARGEMENT
DNA
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Summary:1. A group of weanling rats was made anemic by an Fe- and Cu-deficient diet consisting of cowʼs milk. An appropriate control group receiving Fe and Cu in addition to milk was also studied. After 86–105 days, the rats were sacrificed; hematocrit levels, heart weights, DNA, RNA, and protein concentrations were determined. Total DNA, RNA, and protein contents of the hearts were calculated.2. Statistical analysis showed a significantly increased mean heart weight, decreased DNA concentration, increased RNA to DNA ratio, and increased total RNA and protein content in the hearts of the anemie group of rats versus the control rats. There were no statistically significant changes in RNA concentration or total DNA content of the hearts.3. These data are interpreted as showing that the predominant cellular change in cardiae enlargement in the rat with dietary Fe-and Cu-deficiency is that of increase in size of the myocardial cell.
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ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.12.2.170