Ishige okamurae reduces blood glucose levels in high-fat diet mice and improves glucose metabolism in the skeletal muscle and pancreas

• Published in: Fisheries and aquatic sciences Vol. 23; no. 1; pp. 1 - 9
• Main Authors: Yang, Hye-Won, Son, Myeongjoo, Choi, Junwon, Oh, Seyeon, Jeon, You-Jin, Byun, Kyunghee, Ryu, Bo Mi
• Format: Journal Article
• Language: English
• Published: London BioMed Central 09.09.2020; Springer; The Korean Society of Fisheries and Aquatic Science; 한국수산과학회
• Subjects: Analysis; Animal Ecology; Biomedical and Life Sciences; Blood glucose; diabetes; Diet; Dietary supplements; Fish & Wildlife Biology & Management; high-fat diet mice; House mouse; ishige okamurae; Life Sciences; Marine & Freshwater Sciences; Marine Biotechnology; pancreas; Physiological aspects; Research Article; Skeletal muscle; Type 2 diabetes; Zoology; 수산학; High-fat diet mice; Diabetes; Pancreas; Skeletal muscle
• ISSN: 2234-1757; 2234-1749; 2234-1757
• DOI: 10.1186/s41240-020-00168-5

Brown alga ( Ishige okamurae ; IO) dietary supplements have been reported to possess anti-diabetic properties. However, the effects of IO supplements have not been evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age, 7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group), high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet with 75 mg/kg IO extract (HFD/75/IOE). After 4 weeks, the plasma, pancreas, and skeletal muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and those of their related transcription factors in the pancreases and skeletal muscles of HFD mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the pancreas and skeletal muscle in HFD-induced diabetes.