Mode of ethanol administration influences the severity of hemorrhage-induced lactic acidemia in conscious guinea pigs

• Published in: Journal of cardiovascular pharmacology Vol. 56; no. 3; p. 234
• Main Authors: McDonough, Kathleen H, Swafford, Jr, Albert N, Giaimo, Mary E, Adamson, Trinka W, Miller, Harvey I
• Format: Journal Article
• Language: English
• Published: United States 01.09.2010
• Subjects: Acidosis, Lactic - etiology; Acidosis, Lactic - metabolism; Acidosis, Lactic - physiopathology; Animals; Drug Administration Routes; Ethanol - administration & dosage; Ethanol - blood; Fluid Therapy; Guinea Pigs; Hemorrhage - complications; Hemorrhage - metabolism; Hemorrhage - physiopathology; Isotonic Solutions - therapeutic use; Male; Resuscitation; Shock, Hemorrhagic - etiology; Shock, Hemorrhagic - physiopathology; Time Factors
• ISSN: 1533-4023
• DOI: 10.1097/FJC.0b013e3181e7fd53

Mechanisms that limit metabolic acidemia during shock are limited by ethanol (EtOH). This may be due to (1) loss of respiratory compensation, (2) a greater fall in cardiac output, (3) altered removal of plasma lactate by the liver, and (4) alterations in central nervous system orchestration of compensatory responses. We have previously shown that loss of metabolic compensation during hemorrhage is correlated with plasma EtOH concentrations. The present study determines if the mode of ethanol administration influences compensation during hemorrhage. Male guinea pigs were administered EtOH (1 g/kg, 30% wt/vol) via intraperitoneal (IP) or intragastric (IG) routes. After 30 minutes, 60% of the estimated blood volume was removed. Animals remained in shock for 30 minutes were resuscitated with lactated Ringer solution and monitored for 3 hours. Plasma EtOH levels were similar in the 2 groups at the initiation of, and during, hemorrhage and resuscitation. Animals given EtOH IP exhibited more severe acidemia. The mode of EtOH administration may affect hepatic ethanol and lactate metabolism, thus exacerbating acidemia. An altered central nervous system response may impact compensatory responses during shock. Our results indicate that the "history" of the EtOH episode may be an important determinant in the compensation for hemorrhage and resuscitation.