Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography
The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME...
Saved in:
| Published in | Rapid communications in mass spectrometry Vol. 16; no. 5; pp. 421 - 426 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.01.2002
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high‐throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on‐line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Copyright © 2002 John Wiley & Sons, Ltd. |
|---|---|
| AbstractList | The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high-throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high-throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on-line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Abstract The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high‐throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on‐line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Copyright © 2002 John Wiley & Sons, Ltd. The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high‐throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on‐line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Copyright © 2002 John Wiley & Sons, Ltd. |
| Author | Herman, J. L. |
| Author_xml | – sequence: 1 givenname: J. L. surname: Herman fullname: Herman, J. L. email: jherman@cephalon.com organization: Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11857726$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10M1u1DAUhmELFdFpQdwB8goWKMU_Sews0QBTRAGpLWJpOc7xjCGxB9tRO2tuHFcZwYrVkY4evYvvDJ344AGh55RcUELYm2imi6bjj9CKkk5UhHF6glaka2hV006eorOUfhBCacPIE3RKqWyEYO0K_d6Ah-gMniDvwoBtiDj4anQeMNznqE12weNg8RDnLU5zn7L2BhJ2Hucd4H2EBOXxQHoXxrB1Ro940rlUC5uT81uc59jPI_iM7RjusNnFUETYRr3fHZ6ix1aPCZ4d7zn69uH97fqyuvq6-bh-e1WZmgpeWTLwVtpBSy0ktdLKvmOUGyaattdi4E3d27qrec-bltEWmKUdgGyM0JpCx8_Ry6W7j-HXDCmrySUD46g9hDkpQeuS6liBrxZoYkgpglX76CYdD4oS9bC3KnursneRL47JuZ9g-OeOAxfwegF3boTD_zrqev15yVWLdinD_V-t40_VCi4a9f3LRr27vZHXn24u1Zr_AXK3nO4 |
| CitedBy_id | crossref_primary_10_1016_j_chroma_2005_05_081 crossref_primary_10_1002_rcm_2649 crossref_primary_10_1016_j_jchromb_2003_11_043 crossref_primary_10_1515_CCLM_2003_245 crossref_primary_10_1016_j_jchromb_2009_05_012 crossref_primary_10_1365_s10337_005_0562_3 crossref_primary_10_1016_j_cca_2010_02_067 crossref_primary_10_1007_s00216_012_5768_2 crossref_primary_10_1515_JLM_2006_047 crossref_primary_10_1016_j_ijms_2004_01_021 crossref_primary_10_1365_s10337_009_1097_9 crossref_primary_10_1016_j_jchromb_2007_12_017 crossref_primary_10_1002_bmc_2769 crossref_primary_10_1002_rcm_1843 crossref_primary_10_1002_jms_252 crossref_primary_10_1002_rcm_1327 crossref_primary_10_1002_0471141755_ph0701s30 crossref_primary_10_3724_SP_J_1123_2012_00168 crossref_primary_10_1002_0471141755_ph0701s66 crossref_primary_10_1016_j_cccn_2004_03_017 crossref_primary_10_1016_j_jbbm_2006_10_001 crossref_primary_10_1007_BF02491731 crossref_primary_10_1517_17425250903547829 crossref_primary_10_1002_mas_10050 crossref_primary_10_1002_rcm_1139 crossref_primary_10_1002_rcm_2426 crossref_primary_10_1016_S0731_7085_02_00649_0 crossref_primary_10_1016_j_jpba_2006_05_021 crossref_primary_10_4155_bio_11_137 crossref_primary_10_1002_rcm_784 crossref_primary_10_1016_j_jchromb_2013_02_002 crossref_primary_10_1007_s00216_016_0024_9 crossref_primary_10_1016_j_jpba_2009_10_005 crossref_primary_10_1016_j_jchromb_2007_04_030 crossref_primary_10_1002_rcm_1655 crossref_primary_10_1002_jssc_201401285 crossref_primary_10_1081_JLC_200053022 crossref_primary_10_1016_S0021_9673_03_00506_5 crossref_primary_10_1016_j_aca_2014_01_017 crossref_primary_10_1016_j_aca_2003_12_023 crossref_primary_10_1097_01_ftd_0000194026_04483_c3 crossref_primary_10_1016_S0021_9673_03_00773_8 crossref_primary_10_1016_j_jchromb_2004_09_033 crossref_primary_10_1016_j_jchromb_2024_124124 crossref_primary_10_4155_bio_13_258 crossref_primary_10_1016_j_chroma_2014_05_028 crossref_primary_10_1016_j_jpba_2014_09_030 crossref_primary_10_1016_j_jpba_2004_07_029 crossref_primary_10_1002_rcm_1023 crossref_primary_10_1016_j_ijms_2003_12_040 crossref_primary_10_1016_j_pbb_2003_12_001 crossref_primary_10_1002_rcm_2037 crossref_primary_10_1016_j_jchromb_2007_10_036 crossref_primary_10_1080_10826076_2010_484375 crossref_primary_10_1016_j_jchromb_2009_12_026 crossref_primary_10_1002_jssc_201401321 |
| Cites_doi | 10.1016/S0021-9673(98)00579-2 10.1002/(SICI)1097-0231(199712)11:18<1953::AID-RCM102>3.0.CO;2-Z 10.1002/1099-0801(200010)14:6<422::AID-BMC25>3.0.CO;2-I 10.1002/(SICI)1097-0231(19981015)12:19<1389::AID-RCM329>3.0.CO;2-T |
| ContentType | Journal Article |
| Copyright | Copyright © 2002 John Wiley & Sons, Ltd. Copyright 2002 John Wiley & Sons, Ltd. |
| Copyright_xml | – notice: Copyright © 2002 John Wiley & Sons, Ltd. – notice: Copyright 2002 John Wiley & Sons, Ltd. |
| DBID | BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1002/rcm.593 |
| DatabaseName | Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry |
| EISSN | 1097-0231 |
| EndPage | 426 |
| ExternalDocumentID | 10_1002_rcm_593 11857726 RCM593 ark_67375_WNG_DTS8RKSH_C |
| Genre | article Journal Article |
| GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABHUG ABIJN ABJNI ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACIWK ACPOU ACXBN ACXME ACXQS ADAWD ADBBV ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFVGU AFZJQ AGJLS AHBTC AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BSCLL BY8 CS3 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRSTM DU5 EBS EJD F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.T H.X HBH HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ NNB O66 O9- P2P P2W P2X P4D Q.N Q11 QB0 QRW R.K RNS ROL RWI RX1 SUPJJ TN5 UB1 V2E W8V W99 WBFHL WBKPD WH7 WIB WIH WIK WJL WOHZO WQJ WRC WXSBR WYISQ XG1 XPP XV2 ZCG ZZTAW ~02 ~IA ~WT AITYG HGLYW OIG WRJ 53G ABEML ACSCC AQPKS CGR CUY CVF EBD ECM EIF EMOBN HF~ LH5 NPM PALCI RIWAO RJQFR RYL SAMSI AAYXX CITATION 7X8 |
| ID | FETCH-LOGICAL-c4173-f0d368fda8a781f8f8b9213c2756ba7d354bf4943b356216e2f19ee85c7aa1e93 |
| IEDL.DBID | DR2 |
| ISSN | 0951-4198 |
| IngestDate | Sat Aug 17 00:02:35 EDT 2024 Fri Aug 23 01:24:48 EDT 2024 Sat Sep 28 07:36:54 EDT 2024 Sat Aug 24 01:01:39 EDT 2024 Wed Jan 17 05:00:08 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| License | Copyright 2002 John Wiley & Sons, Ltd. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4173-f0d368fda8a781f8f8b9213c2756ba7d354bf4943b356216e2f19ee85c7aa1e93 |
| Notes | ark:/67375/WNG-DTS8RKSH-C istex:5867995985C64DB5040063C616BF03C9D760B2BB ArticleID:RCM593 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 11857726 |
| PQID | 71475692 |
| PQPubID | 23479 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_71475692 crossref_primary_10_1002_rcm_593 pubmed_primary_11857726 wiley_primary_10_1002_rcm_593_RCM593 istex_primary_ark_67375_WNG_DTS8RKSH_C |
| PublicationCentury | 2000 |
| PublicationDate | 2002-01-01 |
| PublicationDateYYYYMMDD | 2002-01-01 |
| PublicationDate_xml | – month: 01 year: 2002 text: 2002-01-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | Chichester, UK |
| PublicationPlace_xml | – name: Chichester, UK – name: England |
| PublicationTitle | Rapid communications in mass spectrometry |
| PublicationTitleAlternate | Rapid Commun. Mass Spectrom |
| PublicationYear | 2002 |
| Publisher | John Wiley & Sons, Ltd |
| Publisher_xml | – name: John Wiley & Sons, Ltd |
| References | Jemal M, Xia Y-Q, Whigan DB. Rapid Commun. Mass Spectrom. 1998; 12: 1389. Ayrton J, Dear GJ, Leavens WJ, Mallett DN, Plumb RS. Rapid Commun. Mass Spectrom. 1997; 11: 1953. Powell ML, Jemal M. Am. Pharm. Rev. 2001; 4: 63. Jemal M. Biomed. Chromatogr. 2000; 14: 422. Ayrton J, Dear GJ, Leavens WJ, Mallett DN, Plumb RS. J. Chromatogr. A 1998; 828: 199. 1997; 11 2000; 14 2001; 4 1998; 12 1999 1998; 828 Powell ML (e_1_2_5_7_2) 2001; 4 e_1_2_5_3_2 e_1_2_5_2_2 e_1_2_5_6_2 e_1_2_5_5_2 e_1_2_5_4_2 |
| References_xml | – volume: 11 start-page: 1953 year: 1997 publication-title: Rapid Commun. Mass Spectrom. – volume: 14 start-page: 422 year: 2000 publication-title: Biomed. Chromatogr. – volume: 828 start-page: 199 year: 1998 publication-title: J. Chromatogr. A – start-page: 15 year: 1999 end-page: 18 – volume: 4 start-page: 63 year: 2001 publication-title: Am. Pharm. Rev. – volume: 12 start-page: 1389 year: 1998 publication-title: Rapid Commun. Mass Spectrom. – ident: e_1_2_5_4_2 doi: 10.1016/S0021-9673(98)00579-2 – volume: 4 start-page: 63 year: 2001 ident: e_1_2_5_7_2 publication-title: Am. Pharm. Rev. contributor: fullname: Powell ML – ident: e_1_2_5_3_2 doi: 10.1002/(SICI)1097-0231(199712)11:18<1953::AID-RCM102>3.0.CO;2-Z – ident: e_1_2_5_6_2 doi: 10.1002/1099-0801(200010)14:6<422::AID-BMC25>3.0.CO;2-I – ident: e_1_2_5_2_2 – ident: e_1_2_5_5_2 doi: 10.1002/(SICI)1097-0231(19981015)12:19<1389::AID-RCM329>3.0.CO;2-T |
| SSID | ssj0011520 |
| Score | 2.0102866 |
| Snippet | The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely... Abstract The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade.... |
| SourceID | proquest crossref pubmed wiley istex |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 421 |
| SubjectTerms | Animals Brain Chemistry Chromatography, Liquid Mass Spectrometry Online Systems Pharmaceutical Preparations - analysis Pharmaceutical Preparations - blood Pharmaceutical Preparations - urine Rats Reference Standards Reproducibility of Results Solvents |
| Title | Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography |
| URI | https://api.istex.fr/ark:/67375/WNG-DTS8RKSH-C/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Frcm.593 https://www.ncbi.nlm.nih.gov/pubmed/11857726 https://search.proquest.com/docview/71475692 |
| Volume | 16 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZQOcCF9yM8fai4Zbt2nDg-ooWyArWHbSsqLpbt2G1VmlTZjUCcuHDnN_JLmLF3txSBhDjlkHHszHy2J479fYRscudKZ5nKGyVcLoJzuS05YLkq5NgWpRJRtG9nt5oeiLeH5eEvUl-JH2K94IY9I47X2MGNnW9dkIb27mxUKuT5RBo9TIdma-IoSHMSISOKyAv4rk7HZbHk1rLcpXnoKrr085-SzMs5a5x0tm-SD6vmpr0mp6NhYUfuy29Mjv_1PrfIjWUqSl8m7NwmV3x7h1ybrBTg7pJvkZP6xNEkM00hv6Vd--Prd6yMwqjep1MRtAu06YcjOodRaIEwmtOTlkJqSc_j6Sbn0STxPSEo6FkUBgAz3HZ_RGHaswNOfzR87D5Rd9x3YLEk075HDrZf70-m-VK2IXeCySIP46ao6tCY2siahTrUVnFWOCSat0Y2RSlsEAACgELFWeV5YMr7unTSGOZVcZ9stF3rHxLq7TgIFKIIvBFeWcXgkWXBjTRi7CXLCF0FUZ8ndg6deJi5Bn9q8GdGXsTgru-b_hQ3s8lSv999o1_t79Wzd3tTPcnI81X0NfgZ_5uY1nfDXEsmoOmKZ-RBAsVFXcikJXmVkc0Y2r81Qs8mO3B59G9mj8n1qDkTF3qekI1FP_inkPos7LOI8p-LBwPo |
| link.rule.ids | 315,786,790,1382,27957,27958,46329,46753 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagPZQL70d41YeKW7Zrx47jI1ooC-3uYbsVlThYsWOXqjSpshuBOHHhzm_klzC2s1sVgYQ45ZBx4syM7bEz830I7VBjuNFEppVkJmXOmFRzCr6cZ2KoMy5ZIO2bTPPxEXt3zI_7rEpfCxPxIdYHbn5khPnaD3B_IL17iRramvMBl9l1tAmDnYft1GwNHQWBToRk9DTyDHbWsWDWN93tG15ZiTa9Ur_8Kcy8GrWGZWfvFvqw6nDMNjkbdEs9MF9_w3L8vy-6jW720Sh-Gd3nDrpm67toa7QigbuHvgdY6lODI9M0hhAXN_XPbz_82zBM7G0sjMCNw1XbneAFTERL70kLfFpjiC7xRShwMtaLRMgn7xf4PHADgJjPvD_BsPLpzq-A2H1qPmPzsW1AosfTvo-O9l7PR-O0Z25IDSMiS92wyvLCVWVRioK4whVaUpIZjzWvS1FlnGnHwA_AG3JKcksdkdYW3IiyJFZmD9BG3dT2EcJWDx3zXBSOVsxKLQk8kme0FCUbWkEShFdWVBcRoENFKGaqQJ8K9JmgF8G66_tle-bz2QRX76dv1Kv5YTHbPxyrUYK2V-ZXoGf_66SsbdMtlCAMui5pgh5Gr7h8lwfTEjRP0E6w7d86oWajCVwe_5vYNtoazycH6uDtdP8JuhEoaMK5z1O0sWw7-wwioaV-Hlz-F7_FCAo |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFL2CVgI2vB_hVS8qdpmOH4njJZphGCgdoWkrKjZW7NilKk1GmYlArNiw5xv5EvyYmVIEEmKVRa5j595j-8axzwHYJlpnWmGRVoLplFmtU5URh-Wc8r6imWBBtG9vko8P2euj7OgXqa_ID7FecPM9I4zXvoPPKrtzThra6rNeJuhl2GQ5JR7Qw-maOcrlOZGR0avIM_dhHc_L-qI7y4IXJqJN79PPf8oyLyatYdYZ3YD3q_bGzSanvW6hevrLb1SO__VCN-H6MhdFzyN4bsElU9-Gq4OVBNwd-BZIqU80ijrTyCW4qKl_fP3uK0NuWG_jsQjUWFS13TGau2Fo4XE0Ryc1crklmoXjTdp4k0j45FGBzoIygDPz--6PkZv3VOfnP2Q_Np-Q_tA2zmLJpn0XDkcvDgbjdKnbkGqGOU1tv6J5YauyKHmBbWELJQim2jPNq5JXNGPKMocCh4Wc4NwQi4UxRaZ5WWIj6D3YqJvaPABkVN8yr0RhScWMUAK7R2aUlLxkfcNxAmgVRDmL9BwyEjET6fwpnT8TeBaCu75ftqd-NxvP5LvJSzk82C-mu_tjOUhgaxV96fzsf5yUtWm6ueSYuaYLksD9CIrzujyVFid5AtshtH9rhJwO9tzl4b-ZbcGVt8ORfPNqsvsIrgX9mbDo8xg2Fm1nnrg0aKGeBsD_BLTnBrk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Generic+method+for+on%E2%80%90line+extraction+of+drug+substances+in+the+presence+of+biological+matrices+using+turbulent+flow+chromatography&rft.jtitle=Rapid+communications+in+mass+spectrometry&rft.au=Herman%2C+J.+L.&rft.date=2002-01-01&rft.issn=0951-4198&rft.eissn=1097-0231&rft.volume=16&rft.issue=5&rft.spage=421&rft.epage=426&rft_id=info:doi/10.1002%2Frcm.593&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_rcm_593 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0951-4198&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0951-4198&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0951-4198&client=summon |