Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography

The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME...

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Bibliographic Details
Published inRapid communications in mass spectrometry Vol. 16; no. 5; pp. 421 - 426
Main Author Herman, J. L.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.01.2002
Subjects
Animals
Brain Chemistry
Chromatography, Liquid
Mass Spectrometry
Online Systems
Pharmaceutical Preparations - analysis
Pharmaceutical Preparations - blood
Pharmaceutical Preparations - urine
Rats
Reference Standards
Reproducibility of Results
Solvents
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Summary:The use of liquid chromatography/mass spectrometry (LC/MS) to quantify drugs in biological matrices has been well established over the last decade. Extremely fast LC/MS methods are commonplace in the pharmaceutical industry for high‐throughput Absorption, Distribution, Metabolism and Excretion (ADME) screening. However, to truly take full advantage of high‐throughput ADME screening, a generic method is needed that eliminates the need to develop a new method for each new compound being screened. New developments in the stationary phase of turbulent flow columns has allowed us to develop an on‐line biological sample cleanup method that is suitable for over 99% of the compounds in the Cephalon database. Copyright © 2002 John Wiley & Sons, Ltd.
Bibliography:ark:/67375/WNG-DTS8RKSH-C
istex:5867995985C64DB5040063C616BF03C9D760B2BB
ArticleID:RCM593
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.593