Rat visual cortical neurones express TrkA NGF receptor

In this study we report the expression of TrkA receptor within the rat visual cortex during postnatal development and in adulthood, using a specific monoclonal antibody which recognizes the extracellular domain of TrkA receptor. TrkA was not detected by immunohistochemistry at postnatal day 13 (P13)...

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Bibliographic Details
Published inNeuroreport Vol. 13; no. 10; p. 1369
Main Authors Tropea, Daniela, Capsoni, Simona, Covaceuszach, Sonia, Domenici, Luciano, Cattaneo, Antonino
Format Journal Article
LanguageEnglish
Published England 19.07.2002
Subjects
Age Factors
Animals
Antibodies, Monoclonal
Antibody Specificity
Critical Period (Psychology)
Immunohistochemistry
Neurons - chemistry
Rats
Rats, Wistar
Receptor, trkA - analysis
Receptor, trkA - immunology
Visual Cortex - cytology
Visual Cortex - growth & development
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Summary:In this study we report the expression of TrkA receptor within the rat visual cortex during postnatal development and in adulthood, using a specific monoclonal antibody which recognizes the extracellular domain of TrkA receptor. TrkA was not detected by immunohistochemistry at postnatal day 13 (P13), i.e. before eye opening. At P22 TrkA was mostly localised in cortical fibre-like processes. At P39 and P90, TrkA-positive neuronal cell bodies in supragranular and infragranular layers were found. Using double immunohistochemistry, labelled cells were identified as intrinsic cholinergic neurones, and as interneurones expressing calbindin and neuropeptide Y. We conclude that TrkA is expressed in visual cortical neurones during postnatal development and in adulthood and that its pattern of expression is developmentally regulated.
ISSN:0959-4965
DOI:10.1097/00001756-200207190-00031