Patients Requiring Conversion to General Anesthesia during Endovascular Therapy Have Worse Outcomes: A Post Hoc Analysis of Data from the SAGA Collaboration

• Published in: American journal of neuroradiology : AJNR Vol. 41; no. 12; pp. 2298 - 2302
• Main Authors: Simonsen, C Z, Schönenberger, S, Hendén, P L, Yoo, A J, Uhlmann, L, Rentzos, A, Bösel, J, Valentin, J, Rasmussen, M
• Format: Journal Article
• Language: English
• Published: United States American Society of Neuroradiology 01.12.2020
• Subjects: Aged; Aged, 80 and over; Anestesi och intensivvård; Anesthesia, General; Anesthesiology and Intensive Care; Conscious Sedation; Endovascular Procedures - methods; Female; Humans; Interventional; Ischemic Stroke - surgery; Male; Middle Aged; Neurologi; Neurology; Radiologi och bildbehandling; Radiology, Nuclear Medicine and Medical Imaging; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors; Treatment Outcome
• ISSN: 0195-6108; 1936-959X; 1936-959X
• DOI: 10.3174/ajnr.A6823

Endovascular therapy for acute ischemic stroke is often performed with the patient under conscious sedation. Emergent conversion from conscious sedation to general anesthesia is sometimes necessary. The aim of this study was to assess the functional outcome in converted patients compared with patients who remained in conscious sedation and to identify predictors associated with the risk of conversion. Data from 368 patients, included in 3 trials randomizing between conscious sedation and general anesthesia before endovascular therapy (SIESTA, ANSTROKE, and GOLIATH) constituted the study cohort. Twenty-one (11%) of 185 patients randomized to conscious sedation were emergently converted to general anesthesia. Absence of hyperlipidemia seemed to be the strongest predictor of conversion to general anesthesia, albeit a weak predictor (area under curve = 0.62). Sex, hypertension, diabetes, smoking status, atrial fibrillation, blood pressure, size of the infarct, and level and side of the occlusion were not significantly associated with conversion to general anesthesia. Neither age (mean age, 71.3   ± 13.8 years for conscious sedation versus 71.6  ± 12.3 years for converters, = .58) nor severity of stroke (mean NIHSS score, 17 ± 4 versus 18 ± 4, respectively, = .27) were significantly different between converters and those who tolerated conscious sedation. The converters had significantly worse outcome with a common odds ratio of 2.67 ( = .015) for a shift toward a higher mRS score compared with the patients remaining in the conscious sedation group. Patients undergoing conversion had significantly worse outcome compared with patients remaining in conscious sedation. No factor was identified that predicted conversion from conscious sedation to general anesthesia.