Comparison of Live, Attenuated H1N1 and H3N2 Cold-Adapted and Avian-Human Influenza A Reassortant Viruses and Inactivated Virus Vaccine in Adults
The infectivity, immunogenicity, and efficacy of live,attenuated influenza A/Texas/1/85 (H1N1) and A/Bethesda/1/85 (H3N2) avian-human (ah) and cold-adapted (ca) reassortant vaccines were compared in 252 seronegative adult volunteers. The immunogenicity and efficacy of the H1N1 reassortant vaccine we...
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Published in | The Journal of infectious diseases Vol. 158; no. 6; pp. 1209 - 1219 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chicago, IL
The University Chicago Press
01.12.1988
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | The infectivity, immunogenicity, and efficacy of live,attenuated influenza A/Texas/1/85 (H1N1) and A/Bethesda/1/85 (H3N2) avian-human (ah) and cold-adapted (ca) reassortant vaccines were compared in 252 seronegative adult volunteers. The immunogenicity and efficacy of the H1N1 reassortant vaccine were also compared with those of the trivalent inactivated virus vaccine. Each reassortant vaccine was satisfactorily attenuated. The 50% human infectious dose was 104.9 for ca H1N1, 105.4 for ah H1N1, 106.4 for ca H3N2, and 106.5 TCID50 for ah H3N2 reassortant virus. Within a subtype, the immunogenicities of ah and ca vaccines were comparable. Five to seven weeks after vaccination, volunteers were challenged with homologous wild-type influenza A virus. The magnitude of shedding of virus after challenge was >100-fold less in H1N1 vaccinees and >10-fold less in H3N2 vaccinees compared with unimmunized controls. The vaccines were equally efficacious, as indicated by an 86%-100% reduction in illness. Thus, the ah A/Mallard/New York/6750/78 and the ca A/Ann Arbor/6/60 reassortant viruses are comparable. |
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Bibliography: | Please address requests for reprints to Dr. Mary Lou Clements, Center for Immunization Research, The Johns Hopkins University, 624 North Broadway, Room 109, Baltimore, Maryland 21205. istex:1E2D3301874EC0C7B77DF3C1C898AE6BF2A96DCB ark:/67375/HXZ-5QWVLS4V-0 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/158.6.1209 |