Heat-Shock Mannoproteins as Targets of Secretory IgA in Candida albicans
The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells we...
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| Published in | The Journal of infectious diseases Vol. 169; no. 6; pp. 1401 - 1405 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chicago, IL
The University of Chicago Press
01.06.1994
University of Chicago Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells were positive by an indirect immunofluorescence assay after being incubated at 37°C but not at 25°C. In vitro temperature-inducible C. albieans antigenic determinants reactive with secretory IgA were characterized by radioimmune Western blot as mannoproteins with molecular masses of 180–200, 130–150, 90–110, and 60–70 kDa. This is the first report on the expression of mannoproteins regulated by temperature involved in the secretory immune response during mucosal candidiasis. |
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| AbstractList | The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells were positive by an indirect immunofluorescence assay after being incubated at 37°C but not at 25°C. In vitro temperature-inducible C. albieans antigenic determinants reactive with secretory IgA were characterized by radioimmune Western blot as mannoproteins with molecular masses of 180–200, 130–150, 90–110, and 60–70 kDa. This is the first report on the expression of mannoproteins regulated by temperature involved in the secretory immune response during mucosal candidiasis. The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells were positive by an indirect immunofluorescence assay after being incubated at 37 degrees C but not at 25 degrees C. In vitro temperature-inducible C. albicans antigenic determinants reactive with secretory IgA were characterized by radioimmune Western blot as mannoproteins with molecular masses of 180-200, 130-150, 90-110, and 60-70 kDa. This is the first report on the expression of mannoproteins regulated by temperature involved in the secretory immune response during mucosal candidiasis. The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells were positive by an indirect immunofluorescence assay after being incubated at 37 degree C but not at 25 degree C. In vitro temperature-inducible C. albicans antigenic determinants reactive with secretory IgA were characterized by radioimmune Western blot as mannoproteins with molecular masses of 180-200, 130-150, 90-110, and 60-70 kDa. This is the first report on the expression of mannoproteins regulated by temperature involved in the secretory immune response during mucosal candidiasis. The expression of Candida albicans antigenic determinants reacting with secretory IgA from patients with oral and vaginal candidiasis was investigated under different in vitro conditions. Reversible antigenic transitions were inducible in synthetic medium by temperature shifts, as the yeast cells were positive by an indirect immunofluorescence assay after being incubated at 37°C but not at 25°C. In vitro temperature-inducible C albicans antigenic determinants reactive with secretory IgA were characterized by radioimmune Western blot as mannoproteins with molecular masses of 180-200, 130-150, 90-110, and 60-70 kDa. This is the first report on the expression of mannoproteins regulated by temperature involved in the secretory immune response during mucosal candidiasis. |
| Author | Hernando, F. L. Conti, S. Cantelli, C. Gerloni, M. Polonelli, L. Barea, P. L. Portincasa, P. Ponton, J. Almondo, F. Fisicaro, P. |
| Author_xml | – sequence: 1 givenname: L. surname: Polonelli fullname: Polonelli, L. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 2 givenname: M. surname: Gerloni fullname: Gerloni, M. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 3 givenname: S. surname: Conti fullname: Conti, S. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 4 givenname: P. surname: Fisicaro fullname: Fisicaro, P. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 5 givenname: C. surname: Cantelli fullname: Cantelli, C. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 6 givenname: P. surname: Portincasa fullname: Portincasa, P. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 7 givenname: F. surname: Almondo fullname: Almondo, F. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 8 givenname: P. L. surname: Barea fullname: Barea, P. L. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 9 givenname: F. L. surname: Hernando fullname: Hernando, F. L. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain – sequence: 10 givenname: J. surname: Ponton fullname: Ponton, J. organization: Istituto di Microbiologia, Università degli Studi di Parma, Italy, Bilbao, Spain |
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| Copyright | Copyright 1994 The University of Chicago 1994 INIST-CNRS |
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| Keywords | Candida albicans Human Candidiasis IgA Mycosis Antigenic determinant Stomatology Gene expression In vitro Female genital diseases Fungi Infection Immunological investigation Heat shock protein Immunoblotting assay Fungi Imperfecti Thallophyta |
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| SubjectTerms | Antibodies, Fungal - immunology Biological and medical sciences Blotting, Western Candida albicans Candidiasis Candidiasis - immunology Candidiasis, Oral - immunology Candidiasis, Vulvovaginal - immunology Concise Communications Ent and stomatologic mycoses Epithelial cells Epitopes Female Fluorescent Antibody Technique Heat-Shock Proteins - immunology Human mycoses Humans Immunoglobulin A, Secretory - immunology Infectious diseases Medical sciences Membrane Glycoproteins - immunology Monoclonal antibodies Mycoses Oxidation Reactivity Saliva Temperature Washing Yeasts |
| Title | Heat-Shock Mannoproteins as Targets of Secretory IgA in Candida albicans |
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