Predictors of restenosis after excimer laser coronary angioplasty

• Published in: The American journal of cardiology Vol. 75; no. 15; pp. 1012 - 1014
• Main Authors: Ghazzal, Ziyad M.B., Burton, Erick, Weintraub, William S., Litvack, Frank, Rothbaum, Donald A., Klein, Larry, King, Spencer B.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.05.1995; Elsevier; Elsevier Limited
• Subjects: Aged; Angioplasty; Angioplasty, Laser; Biological and medical sciences; Cardiology. Vascular system; Chi-Square Distribution; Constriction, Pathologic - diagnostic imaging; Constriction, Pathologic - surgery; Coronary Angiography; Coronary Disease - diagnostic imaging; Coronary Disease - surgery; Coronary heart disease; Coronary vessels; Coronary Vessels - surgery; Female; Heart; Humans; Lasers; Logistic Models; Male; Medical research; Medical sciences; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Recurrence; Human; Restenosis; Predictor; Instrumentation therapy; Cuffed tube; Cardiovascular disease; Instrumental dilatation; Coronary heart disease; Percutaneous route
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(99)80714-0

One hundred twenty-five lesions successfully treated with excimer laser coronary angioplasty at 3 centers were analyzed in a central core laboratory using detailed quantitative angiographic analysis. Sixty-seven narrowings had restenosis (≥50% diameter stenosis at restudy). Correlates of restenosis were as follows: baseline diameter stenosis was 79% in the restenosis group versus 71% in the group without restenosis (p = 0.0002), baseline minimal diameter stenosis was 0.55 mm in the restenosis group versus 0.72 mm in the group without restenosis (p = 0.006), final diameter stenosis was 40% in the restenosis group versus 32% in the group without restenosis (p = 0.002), lesion length ≥7 mm was present in 43% of the restenosis group versus 21% in the group without restenosis (p = 0.009), and Thrombolysis in Myocardial Infarction trial flow 0 to 2 was 33% in the restenosis group versus 15% in the group without restenosis (p = 0.025). The strongest multivariate correlate of restenosis was the baseline diameter stenosis (p = 0.003). Whereas most predictors were not controllable, achieving a low residual diameter stenosis that is operator-dependent can favorably influence the restenosis rate.