How to kill an ERKsome target: PROTACs deliver the deathblow

In this issue of Cell Chemical Biology, You et al. demonstrate that selective degradation of ERK5 exhibits neither anti-proliferative nor anti-inflammatory activities previously attributed to ERK5 inactivation. This settles a longstanding debate in the field and highlights the power of PROTACs to in...

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Bibliographic Details
Published inCell chemical biology Vol. 29; no. 11; pp. 1569 - 1571
Main Author Potts, Malia B.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 17.11.2022
Subjects
Proteins - metabolism
Proteolysis
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Summary:In this issue of Cell Chemical Biology, You et al. demonstrate that selective degradation of ERK5 exhibits neither anti-proliferative nor anti-inflammatory activities previously attributed to ERK5 inactivation. This settles a longstanding debate in the field and highlights the power of PROTACs to investigate non-enzymatic activities of target proteins. In this issue of Cell Chemical Biology, You et al. demonstrate that selective degradation of ERK5 exhibits neither anti-proliferative nor anti-inflammatory activities previously attributed to ERK5 inactivation. This settles a longstanding debate in the field and highlights the power of PROTACs to investigate non-enzymatic activities of target proteins.
ISSN:2451-9456
2451-9448
2451-9456
DOI:10.1016/j.chembiol.2022.11.002