Virulence Traits in Escherichia Coli Strains Isolated from Outpatients with Urinary Tract Infections

This study aims to characterize phenotypic and genotypic virulence traits in Escherichia coli strains, isolated from outpatients with urinary tract infections, comparing with those obtained from inpatients. Information on the pathogenic behavior of the uropathogenic strains was obtained by monitorin...

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Published inInternational journal of immunopathology and pharmacology Vol. 21; no. 3; pp. 715 - 723
Main Authors Longhi, C., Cossu, A., Iebba, V., Massaro, M.R., Cipriani, D., Chiarini, F., Conte, M.P., Seganti, L., Osborn, J., Schippa, S.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.07.2008
Subjects
Agglutination
Bacterial Adhesion
Biofilms
Escherichia coli
Escherichia coli - pathogenicity
Escherichia coli - physiology
Female
Humans
Male
Outpatients
Phylogeny
Urinary Tract Infections - microbiology
Virulence Factors - genetics
virulence determinants
outpatients
UTI
Escherichia coli
uropathogenic E. coli
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Summary:This study aims to characterize phenotypic and genotypic virulence traits in Escherichia coli strains, isolated from outpatients with urinary tract infections, comparing with those obtained from inpatients. Information on the pathogenic behavior of the uropathogenic strains was obtained by monitoring different biological properties, such as autoagglutination, hemagglutination, adhesiveness to and invasion of human bladder (HT1376) cells, biofilm formation, phylogenetic grouping, and virulence-related genes. The results show similar behavior in the two groups concerning autoagglutination, hemagglutination, and biofilm formation. None of the strains examined was invasive. However, in strains from outpatients there was an increased adhesion to HT1376 cells compared with clinical strains, a significant higher presence of genes codifying for adhesins and cell protection factors, and a lower proportion of strains belonging to B1 group. These findings add further information on the pathogenic traits of community E. coli, since strains isolated from the outpatients' group were differently “armed” in comparison with those of clinical cases, and more suitable to infect healthy individuals.
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ISSN:0394-6320
2058-7384
DOI:10.1177/039463200802100326