PharmacoDB 2.0: improving scalability and transparency of in vitro pharmacogenomics analysis

Abstract Cancer pharmacogenomics studies provide valuable insights into disease progression and associations between genomic features and drug response. PharmacoDB integrates multiple cancer pharmacogenomics datasets profiling approved and investigational drugs across cell lines from diverse tissue...

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Published inNucleic acids research Vol. 50; no. D1; pp. D1348 - D1357
Main Authors Feizi, Nikta, Nair, Sisira Kadambat, Smirnov, Petr, Beri, Gangesh, Eeles, Christopher, Esfahani, Parinaz Nasr, Nakano, Minoru, Tkachuk, Denis, Mammoliti, Anthony, Gorobets, Evgeniya, Mer, Arvind Singh, Lin, Eva, Yu, Yihong, Martin, Scott, Hafner, Marc, Haibe-Kains, Benjamin
Format Journal Article
LanguageEnglish
Published England Oxford University Press 07.01.2022
Subjects
Database Issue
Databases, Genetic
Genomics - methods
Humans
Pharmacogenetics - standards
Pharmacogenomic Testing - methods
Software
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Summary:Abstract Cancer pharmacogenomics studies provide valuable insights into disease progression and associations between genomic features and drug response. PharmacoDB integrates multiple cancer pharmacogenomics datasets profiling approved and investigational drugs across cell lines from diverse tissue types. The web-application enables users to efficiently navigate across datasets, view and compare drug dose–response data for a specific drug-cell line pair. In the new version of PharmacoDB (version 2.0, https://pharmacodb.ca/), we present (i) new datasets such as NCI-60, the Profiling Relative Inhibition Simultaneously in Mixtures (PRISM) dataset, as well as updated data from the Genomics of Drug Sensitivity in Cancer (GDSC) and the Genentech Cell Line Screening Initiative (gCSI); (ii) implementation of FAIR data pipelines using ORCESTRA and PharmacoDI; (iii) enhancements to drug–response analysis such as tissue distribution of dose–response metrics and biomarker analysis; and (iv) improved connectivity to drug and cell line databases in the community. The web interface has been rewritten using a modern technology stack to ensure scalability and standardization to accommodate growing pharmacogenomics datasets. PharmacoDB 2.0 is a valuable tool for mining pharmacogenomics datasets, comparing and assessing drug–response phenotypes of cancer models. Graphical Abstract Graphical abstract PharmacoDB 2.0 : Improving scalability and transparency of in vitro pharmacogenomics analysis.
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The authors wish it to be known that, in their opinion, the first three authors should be regarded as Joint First Authors.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkab1084