Mitochondrial Translation Initiation Factor 3: Structure, Functions, Interactions, and Implication in Human Health and Disease

Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including...

Full description

Saved in:
Bibliographic Details
Published inBiochemistry (Moscow) Vol. 84; no. 10; pp. 1143 - 1150
Main Authors Chicherin, I. V., Baleva, M. V., Levitskii, S. A., Dashinimaev, E. B., Krasheninnikov, I. A.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.10.2019
Springer
Springer Nature B.V
Subjects
Amino acids
Analysis
Bacterial proteins
Biochemistry
Biological evolution
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Chloroplasts
Development and progression
Electron transfer
Gene expression
Genetic aspects
Genetic translation
Genomics
Health aspects
Life Sciences
Microbiology
Mini-Review
Mitochondria
Mitochondrial DNA
Mutation
Organelles
Parkinson's disease
Protein biosynthesis
Protein synthesis
Respiratory function
Structure
Transfer RNA
Translation
Yeast
Russia
IF3mt
translation
ribosome
mitochondria
Parkinson’s disease
Online AccessGet full text

Cover

More Information
Summary:Mitochondria are essential organelles of eukaryotic cell that provide its respiratory function by means of the electron transfer chain. Expression of mitochondrial genes is organized in a bacterial-like manner; however multiple evolutionary differences are observed between the two systems, including translation initiation machinery. This review is dedicated to the mitochondrial translation initiation factor 3 (IF3mt), which plays a key role in the protein synthesis in mitochondria. Involvement of IF3mt in human health and disease is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297919100031