Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails

In this review, we discuss recent advances made on histone methylation and its diverse functions in regulating gene expression. Methylation of histone polypeptides might be static and might mark a gene to be or not be transcribed. However, the decision to methylate or not methylate a specific residu...

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Bibliographic Details
Published inGenes & development Vol. 15; no. 18; pp. 2343 - 2360
Main Authors Zhang, Y, Reinberg, D
Format Journal Article
LanguageEnglish
Published United States 15.09.2001
Subjects
Amino Acid Sequence
Animals
DNA Methylation
Gene Expression Regulation
histone methyltransferase
Histones - chemistry
Histones - metabolism
Humans
Molecular Sequence Data
Sequence Homology, Amino Acid
Transcription, Genetic
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Summary:In this review, we discuss recent advances made on histone methylation and its diverse functions in regulating gene expression. Methylation of histone polypeptides might be static and might mark a gene to be or not be transcribed. However, the decision to methylate or not methylate a specific residue in the histone polypeptides is an active process that requires coordination among different covalent modifications occurring at the amino termini of the histone polypeptides, the histone tails. Below, we summarize recent advances on histone methyltransferases, and we discuss histone methylation within the context of other histone tail modifications.
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ISSN:0890-9369
1549-5477
DOI:10.1101/gad.927301