Exploring the Genomes of Cancer Cells: Progress and Promise

• Published in: Science (American Association for the Advancement of Science) Vol. 331; no. 6024; pp. 1553 - 1558
• Main Author: Stratton, Michael R.
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 25.03.2011
• Subjects: Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Cancer; DNA; DNA Repair; Drug Discovery; Genes; Genes, Neoplasm; Genetic mutation; Genetic Techniques; Genome, Human; Genomes; Genomics; Humans; Molecular Targeted Therapy; Mutation; Neoplasm Metastasis; Neoplasms - diagnosis; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; Oncogenes; REVIEWS; Sequence Analysis, DNA; Sequencing; Somatic mutation; Tumors

The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the for...