Exploring the Genomes of Cancer Cells: Progress and Promise
The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the for...
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Published in | Science (American Association for the Advancement of Science) Vol. 331; no. 6024; pp. 1553 - 1558 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
United States
American Association for the Advancement of Science
25.03.2011
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Subjects | |
Online Access | Get full text |
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Summary: | The description and interpretation of genomic abnormalities in cancer cells have been at the heart of cancer research for more than a century. With exhaustive sequencing of cancer genomes across a wide range of human tumors well under way, we are now entering the end game of this mission. In the forthcoming decade, essentially complete catalogs of somatic mutations will be generated for tens of thousands of human cancers. Here, I provide an overview of what these efforts have revealed to data about the origin and behavioral features of cancer cells and how this genomic information is being exploited to improve diagnosis and therapy of the disease. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.1204040 |