Effects of 1-year treatment with fluvastatin or pravastatin on bone

• Published in: The American journal of medicine Vol. 110; no. 7; pp. 584 - 587
• Main Authors: Watanabe, Sumiyo, Fukumoto, Seiji, Takeuchi, Yasuhiro, Fujita, Hiroko, Nakano, Tadasumi, Fujita, Toshiro
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.05.2001; Elsevier; Elsevier Sequoia S.A
• Subjects: Aged; Anticholesteremic Agents - pharmacology; Anticholesteremic Agents - therapeutic use; Biological and medical sciences; Bone and Bones - drug effects; Bone and Bones - metabolism; Bone Density; Bones; Bones, joints and connective tissue. Antiinflammatory agents; Fatty Acids, Monounsaturated - pharmacology; Fatty Acids, Monounsaturated - therapeutic use; Female; Fluvastatin; Humans; Hypercholesterolemia - drug therapy; Indoles - pharmacology; Indoles - therapeutic use; Medical sciences; Metabolism; Pharmacology. Drug treatments; Postmenopause; Pravastatin - pharmacology; Pravastatin - therapeutic use; Proteins; Therapy; Human; Statistical analysis; Enzyme; Treatment efficiency; Diseases of the osteoarticular system; Enzyme inhibitor; Metabolic diseases; Pravastatin; Chemotherapy; Association; Fluvastatin; Hypercholesterolemia; Bone mass; Female genital system; Postmenopause; Hydroxymethylglutaryl-CoA reductase; Female; Oxidoreductases; Comparative study; Antilipemic agent
• ISSN: 0002-9343; 1555-7162
• DOI: 10.1016/S0002-9343(01)00679-9

A study conducted to investigate whether the usual doses of stains affect bone metabolism and bone mass is discussed. The effects on bone of pravastatin, which is hydrophilic, and fluvastatin, which is lipophilic, were compared.