A nucleotide diphosphate kinase mediates tethering between mitochondria prior to fusion

Mitochondrial fusion plays an important role in both their structure and function. In this issue, Su et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202301091) report that a nucleoside diphosphate kinase, NME3, facilitates mitochondrial tethering prior to fusion through its direct membrane-bi...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 222; no. 10; p. 1
Main Authors Ikeda, Arisa, Iijima, Miho, Sesaki, Hiromi
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 02.10.2023
Subjects
Diphosphates
Humans
Kinases
Membrane fusion
Mitochondria
Mitochondria - genetics
Mitochondrial Dynamics
NM23 Nucleoside Diphosphate Kinases - genetics
Nucleoside-diphosphate kinase
Nucleotides
Phosphorylation
Spotlight
Structure-function relationships
Tethering
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Summary:Mitochondrial fusion plays an important role in both their structure and function. In this issue, Su et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202301091) report that a nucleoside diphosphate kinase, NME3, facilitates mitochondrial tethering prior to fusion through its direct membrane-binding and hexamerization but not its kinase activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202309037