Regulation of defeat-induced social avoidance by medial amygdala DRD1 in male and female prairie voles

• Published in: Psychoneuroendocrinology Vol. 113; p. 104542
• Main Authors: Tickerhoof, Maria C., Hale, Luanne H., Butler, Michael J., Smith, Adam S.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2020
• Subjects: Amygdala - metabolism; Animals; Anxiety; Arvicolinae; Behavior, Animal - physiology; Corticomedial Nuclear Complex - metabolism; Dopamine; Female; Male; Medial amygdala; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D1 - physiology; Social Behavior; Social Defeat; Stress; Stress, Psychological - metabolism; Stress, Psychological - physiopathology; Anxiety; Dopamine; Social behavior; Social defeat; Stress; Medial amygdala
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2019.104542

•Prairie voles of both sexes experience nearly identical aggression during defeat.•Social defeat causes voles to avoid an unfamiliar conspecific.•Dopamine receptor 1 (DRD1) in the medial amygdala (MeA) increases after defeat.•Increased MeA DRD1 activity induces social avoidance without defeat experience.•Decreased MeA DRD1 activity nearly reverses social avoidance after defeat. Social interaction with unfamiliar individuals is necessary for species-preserving behaviors such as finding mates and establishing social groups. However, social conflict is a potential negative outcome to interaction with a stranger that can be distressing enough to cause an individual to later avoid interactions with other unfamiliar conspecifics. Unfortunately, stress research using a prominent model of social conflict, social defeat stress, has largely omitted female subjects. This has left a void in the literature regarding social strain on female stress biology and adequate comparison of the effect of sex in stress pathways. The prairie vole (Microtus ochrogaster) exhibits aggressive behavior in both sexes, making voles an attractive candidate to model social defeat in both sexes. This study sought to establish a model of social defeat stress in both male and female prairie voles, characterize behavioral changes in response to this stressor, and investigate the role of dopamine signaling in the response to social defeat stress. Defeated male and female prairie voles displayed social avoidance as well as an increase in the level of dopamine receptor D1 (DRD1) in the medial amygdala (MeA). Pharmacological manipulation of DRD1 signaling in the MeA revealed that increased DRD1 signaling is sufficient to induce a social avoidant state, and could be a necessary component in the defeat-induced social avoidance response. These findings provide the prairie vole as a model of social defeat in both sexes, and implicate the MeA in avoidance of unfamiliar conspecifics after a distressing social encounter.