Synthesis and biological activity of novel oxazolidinones

• Published in: Bioorganic & medicinal chemistry letters Vol. 19; no. 22; pp. 6424 - 6428
• Main Authors: Das, Biswajit, Rajarao, A.V.S., Rudra, Sonali, Yadav, Ajay, Ray, Abhijit, Pandya, Manisha, Rattan, Ashok, Mehta, Anita
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 15.11.2009; Elsevier
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Antibacterial; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria; Biological and medical sciences; Drug Design; Furans; Medical sciences; Microbial Sensitivity Tests; Nitro-furan; Oxazoles; Oxazolidinone; Oxazolidinones - chemical synthesis; Oxazolidinones - pharmacology; Pharmacology. Drug treatments; Ranbezolid; Vancomycin Resistance; Nitro-furan; Oxazolidinone; Antibacterial; Ranbezolid; Enterococcus faecalis; Nitro compound; Furan derivatives; Thioureas; Meticillin; Thioamide; Bacteria; Micrococcales; Streptococcus pyogenes; Micrococcaceae; Chemical synthesis; Staphylococcus aureus; In vitro; Biological activity; Streptococcus pneumoniae; Resistance; Streptococcaceae; Oxazolidinone derivative; Piperazine derivatives; Fluorine Organic compounds; Antibacterial agent
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2009.09.054

A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized and their antibacterial activity reported. A number of 5-substituted derivatives of Ranbezolid, a novel oxazolidinone were synthesized. Antibacterial activity of the compounds against a number of sensitive and resistant bacteria showed promising results.