Structural and copy number variants in the human genome: implications for psychiatry

Copy number variants are small chromosomal deletions and duplications. When they alter the dose of genes critical for normal brain development and adult brain functioning they may cause severe disorders such as autism and schizophrenia. Numerous such loci have recently been identified. They are offe...

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Bibliographic Details
Published inBritish journal of psychiatry Vol. 202; no. 1; pp. 5 - 6
Main Author Clair, David St
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 01.01.2013
Subjects
Adult
Autism
Brain
Chromosomes
Consortia
Copy number
Cytogenetics
Deoxyribonucleic acid
DNA
DNA Copy Number Variations - genetics
DNA methylation
Editorials
Epigenetics
Genes
Genome, Human - genetics
Genomes
Genomics
Humans
Intellectual disabilities
Mental disorders
Mental Disorders - genetics
Microscopy
Mutation
Psychiatry
Schizophrenia
Variants
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Summary:Copy number variants are small chromosomal deletions and duplications. When they alter the dose of genes critical for normal brain development and adult brain functioning they may cause severe disorders such as autism and schizophrenia. Numerous such loci have recently been identified. They are offering amazing leads for neuropsychiatric research.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.bp.112.109579