PolySia-Specific Retargeting of Oncolytic Viruses Triggers Tumor-Specific Immune Responses and Facilitates Therapy of Disseminated Lung Cancer

• Published in: Cancer immunology research Vol. 3; no. 7; p. 751
• Main Authors: Kloos, Arnold, Woller, Norman, Gürlevik, Engin, Ureche, Cristina-Ileana, Niemann, Julia, Armbrecht, Nina, Martin, Nikolas T, Geffers, Robert, Manns, Michael P, Gerardy-Schahn, Rita, Kühnel, Florian
• Format: Journal Article
• Language: English
• Published: United States 01.07.2015
• Subjects: Adenoviridae - genetics; Animals; Cell Line, Tumor; Female; Genetic Therapy; Genetic Vectors - genetics; Humans; Lung Neoplasms - therapy; Mice; Mice, Inbred C57BL; Mice, Nude; Oncolytic Virotherapy; Oncolytic Viruses - genetics; Sialic Acids - genetics; T-Lymphocytes - immunology; Xenograft Model Antitumor Assays

Polysialic acid (polySia) is expressed on several malignant tumors of neuroendocrine origin, including small cell lung cancer. In this study, we investigated the therapeutic efficacy of tumor-directed T-cell responses, elicited by polySia-retargeted oncolytic adenovirus infection, in an orthotopic m...