Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes

• Published in: The Lancet (British edition) Vol. 343; no. 8889; pp. 85 - 86
• Main Authors: Smyth, R.L., Smyth, A.R., Lloyd, D.A., van Velzen, D., Heaf, D.P.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 08.01.1994; Lancet; Elsevier Limited
• Subjects: Abdominal Pain - etiology; Adolescent; Biological and medical sciences; Child; Child, Preschool; Children & youth; Colon; Colon - pathology; Colonic Diseases - etiology; Colonic Diseases - pathology; Complex syndromes; Constriction, Pathologic - chemically induced; Cystic fibrosis; Cystic Fibrosis - complications; Cystic Fibrosis - drug therapy; Fibrosis - chemically induced; Humans; Intestinal Obstruction - etiology; Intestinal Obstruction - pathology; Lipase - adverse effects; Male; Meconium; Medical genetics; Medical research; Medical sciences; Pancreatic Extracts - adverse effects; Pancreatin - adverse effects; Pancrelipase; Human; Lung disease; Right colon; Respiratory disease; Enzyme; Lung; Exploration; Congenital disease; Obstruction; Mucoviscidosis; Digestive diseases; Intestinal disease; Colon; Pancreas; Child
• ISSN: 0140-6736; 1474-547X
• DOI: 10.1016/S0140-6736(94)90817-6

We have observed five children with cystic fibrosis, who presented over 2 months, with meconium ileus equivalent that falled to respond to medical management. At surgery, four had a stricture in the ascending colon, and all had histopathological changes of post-ischaemic ulceration repair, with mucosal and submucosal fibrosis. The only common change in the management of these children was a switch from conventional enteric-coated pancreatic enzymes to high-strength products 12–15 months befire presentation.