Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii

Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are th...

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Published inInternational journal of clinical oncology Vol. 28; no. 5; pp. 613 - 624
Main Authors Maehara, Yoshihiko, Oki, Eiji, Ota, Mitsuhiko, Harimoto, Norifumi, Ando, Koji, Nakanishi, Ryota, Kawazoe, Tetsuro, Fujimoto, Yoshiaki, Nonaka, Kentaro, Kitao, Hiroyuki, Iimori, Makoto, Makino, Kunio, Takechi, Teiji, Sagara, Takeshi, Miyadera, Kazutaka, Matsuoka, Kazuaki, Tsukihara, Hiroshi, Kataoka, Yuki, Wakasa, Takeshi, Ochiiwa, Hiroaki, Kamahori, Yoshihiro, Tokunaga, Eriko, Saeki, Hiroshi, Yoshizumi, Tomoharu, Kakeji, Yoshihiro, Shirabe, Ken, Baba, Hideo, Shimada, Mitsuo
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.05.2023
Springer Nature B.V
Subjects
Antineoplastic Agents - therapeutic use
Antineoplastic drugs
Antitumor agents
Cancer Research
Cancer therapies
Chemotherapy
Drug discovery
Drugs
Frontotemporal dementia
Gabexate - therapeutic use
Gastric cancer
Humans
Japan
Kinases
Liver
Male
Medical research
Medicine
Medicine & Public Health
Metabolism
Metabolites
Oncology
Pharmaceuticals
Pravastatin
Pyrimidines
R&D
Regulatory approval
Research & development
Ribonucleotide reductase
Special Article
Surgery
Surgical Oncology
Tegafur - therapeutic use
Uracil
Japan
Senescence
Cancer chemotherapy
5-Fluorouracil
Camostat mesilate
Tegafur
Cetraxate hydrochloride
Gabexate mesilate
Tegafur, gimeracil and oteracil
Tegafur and uracil
Trifluridine and tipiracil hydrochloride
Nafamostat mesilate
Pravastatin sodium
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Summary:Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are therapeutic drugs for various other diseases. He delivered hope to patients with various diseases across the world to improve their condition. Even now, drug discovery research based on Dr. Fujii’s ideas is continuing.
Bibliography:ObjectType-Article-1
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ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-023-02326-w