Suppression of ATP-induced excitability in rat small-diameter trigeminal ganglion neurons by activation of GABAB receptor

• Published in: Brain research bulletin Vol. 98; pp. 155 - 162
• Main Authors: Takeda, Mamoru, Ikeda, Mizuho, Takahashi, Masayuki, Kanazawa, Takuya, Nasu, Masanori, Matsumoto, Shigeji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2013
• Subjects: Action Potentials - drug effects; Adenosine Triphosphate - pharmacology; Analysis of Variance; Animals; Animals, Newborn; Baclofen - analogs & derivatives; Baclofen - pharmacology; Dose-Response Relationship, Drug; GABA Agonists - pharmacology; GABA Antagonists - pharmacology; GABAB receptor; Neurology; Neurons - drug effects; Neurons - physiology; P2X3 receptor; Paracrine; Patch-Clamp Techniques; Rats; Receptors, GABA-B - metabolism; Receptors, Purinergic P2X3 - metabolism; Trigeminal ganglion; Trigeminal Ganglion - cytology; Whole-cell patch clamping; trigeminal ganglia; P 2X3 receptor; SGCs; TRG; ethylene glycol-bis-β-aminoethyl ether N,N,N′,N′-tetraaceticacid; TTX-R; substance P; N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid; PPADS; SP; Whole-cell patch clamping; piperazine-N,N′-bis [2-ethanesulfonic acid]; tetrodotoxin-resistant; calcitonin gene-related peptide; ethylenediaminetetraaceticacid; pyridoxal-phosphate-6-azophenyl-27,47-disulfonic acid; PIPES; EDTA; TRGs; GABA B receptor; EGTA; γ-aminobutyric acid; HEPES; adenosine triphosphate; dorsal root ganglion; Paracrine; GABA; DRG; Trigeminal ganglion; ATP; CGRP; satellite glial cells; GABAB receptor; P2X3 receptor; PX3 receptor; GABA(B) receptor
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2013.08.005

Highlight • Small-TRG neurons co-expressed immunoreactivity of P2 X3 /GABAB receptors. • GABAB receptor activation inhibits the ATP-induced excitability of TRG neurons. • Interaction between P2 X3 and GABAB receptors might be important for trigeminal nociception.