RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles

SARS-CoV-2 depends on host proteins for successful replication. In this issue, Williams et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203060) report that the ER membrane-modulating proteins RTN3 and RTN4 are required for the formation of SARS-CoV-2 replication organelles via direct inter...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 222; no. 7; p. 1
Main Authors Kratzel, Annika, Thiel, Volker
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 03.07.2023
Subjects
Carrier Proteins - genetics
Coronavirus Papain-Like Proteases
COVID-19
Endoplasmic Reticulum
Humans
Membrane Proteins - genetics
Nerve Tissue Proteins - genetics
Nogo Proteins - genetics
Organelles
SARS-CoV-2 - physiology
Severe acute respiratory syndrome coronavirus 2
Spotlight
Viral Nonstructural Proteins
Virology
Virus Replication
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Summary:SARS-CoV-2 depends on host proteins for successful replication. In this issue, Williams et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202203060) report that the ER membrane-modulating proteins RTN3 and RTN4 are required for the formation of SARS-CoV-2 replication organelles via direct interaction with viral proteins NSP3 and NSP4.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Commentary-3
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ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.202306020