Adipogenic potential of skeletal muscle satellite cells

Satellite cells (SCs) are undifferentiated skeletal muscle cells that allow muscular growth and regeneration. Since their first description, SCs were simply considered myogenic precursors, but now it is widely accepted that SCs are a heterogeneous stem cell population characterized by plasticity and...

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Published inClinical Lipidology Vol. 4; no. 2; pp. 245 - 265
Main Authors Sanna, Marta, Franzin, Chiara, Pozzobon, Michela, Favaretto, Francesca, Rossi, Carlo Alberto, Calcagno, Alessandra, Scarda, Alessandro, Dal Pràà, Chiara, Pilon, Catia, Milan, Gabriella, Federspil, Giovanni, De Coppi, Paolo, Vettor, Roberto
Format Journal Article Book Review
LanguageEnglish
Published London Future Medicine Ltd 01.04.2009
Taylor & Francis
Taylor & Francis Ltd
Subjects
adipogenesis
adipogenic differentiation
myogenesis
satellite cell
skeletal muscle
skeletal muscle n stem cell
stem cell
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Summary:Satellite cells (SCs) are undifferentiated skeletal muscle cells that allow muscular growth and regeneration. Since their first description, SCs were simply considered myogenic precursors, but now it is widely accepted that SCs are a heterogeneous stem cell population characterized by plasticity and self-renewal. In this report we focus on SCs capacity to undergo adipogenic differentiation both spontaneous and induced by adipogenic factors. Understanding SC behavior is especially important because their adipogenic potential could represent a pathophysiological explanation for the intramuscular fat depots and associated insulin resistance that characterize many metabolic diseases and age-related sarcopenia. Moreover, SC are a therapeutic promise for neuromuscular diseases in the context of tissue engineering, representing an interesting cell source for implantation.
ISSN:1758-4299
1758-4302
2641-5321
DOI:10.2217/clp.09.8