New-onset Fibromyalgia After Total Knee Replacement in Patients With Osteoarthritis: A Propensity-score-matched Cohort Study in the United States

• Published in: In vivo (Athens) Vol. 38; no. 4; pp. 1957 - 1964
• Main Authors: GAU, SHUO-YAN, LO, SHAO-WEI, CHEN, SHIU-JAU, LIAO, WEN-CHIEH, TSAI, RU-YIN, SU, YU-JUNG, CHANG, HUI-CHIN, LI, CHEN-PI
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.07.2024
• Subjects: Age groups; Aged; Arthroplasty, Replacement, Knee - adverse effects; Collaboration; Electronic health records; Female; Fibromyalgia; Fibromyalgia - complications; Fibromyalgia - epidemiology; Humans; Knee; Male; Males; Middle Aged; Older people; Osteoarthritis; Osteoarthritis, Knee - epidemiology; Osteoarthritis, Knee - etiology; Osteoarthritis, Knee - surgery; Pain; Patients; Propensity Score; Proportional Hazards Models; Quality of life; Retrospective Studies; Risk Factors; Socioeconomic factors; Stress; Surgery; Surgical outcomes; United States - epidemiology; United States; United States > US; epidemiology; cohort; electronic medical records; Total knee replacement; fibromyalgia; osteoarthritis
• ISSN: 0258-851X; 1791-7549; 1791-7549
• DOI: 10.21873/invivo.13652

The risk of new-onset fibromyalgia after total knee replacement (TKR) in osteoarthritis patients is not well-established. This study aimed to assess the risk of developing fibromyalgia post-TKR, considering potential variations across age and sex. Utilizing a multicenter retrospective cohort design and data from the TriNetX research network, electronic health records of osteoarthritis patients who underwent TKR and the same number of matched controls were analyzed. Propensity-score matching was performed by matching critical confounders. Hazard ratios were evaluated to assess fibromyalgia risk in the TKR cohort compared to non-TKR controls. The hazard ratio of future fibromyalgia for the TKR cohort was 2.08 (95% confidence interval=1.74-2.49) for 1 year after the index date, 1.81 (95% confidence interval=1.62-2.02) for 3 years, and 1.69 (95% confidence interval=1.54-1.86) for 5 years compared with non-TKR controls. The significant association remained in sensitivity models and stratification analyses in different age and sex subgroups. Clinicians should be vigilant about the potential for fibromyalgia development post-TKR and consider tailored interventions; our findings emphasize the need for further research to elucidate underlying mechanisms and identify modifiable risk factors.