Association between cognitive performance and sarcopenic obesity in older adults with Alzheimer’s disease

Sarcopenic obesity (SO), the co-occurrence of sarcopenia and obesity, is associated with functional loss, frailty, and incapacity in older adults. Recently, SO was associated with reduced cognitive performance in adults. However, no SO studies have been done with older adults with Alzheimer’s diseas...

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Published inDementia & neuropsychologia Vol. 16; no. 1; pp. 28 - 32
Main Authors Cavazzotto, Timothy Gustavo, Campos, Caroline do Valle de, Mazur, Caryna Eurich, Silva, Danilo Fernandes da, Valério, Juliana Maria Silva, Vieira, Edgar Ramos, Silva, Weber Claudio Francisco Nunes da, Bonini, Juliana Sartori
Format Journal Article
LanguageEnglish
Published Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento 01.01.2022
Associação Neurologia Cognitiva e do Comportamento
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Summary:Sarcopenic obesity (SO), the co-occurrence of sarcopenia and obesity, is associated with functional loss, frailty, and incapacity in older adults. Recently, SO was associated with reduced cognitive performance in adults. However, no SO studies have been done with older adults with Alzheimer’s disease (AD). Objective: The objective of this study was to verify the occurrence of SO and associated factors in 43 older adults with AD. Methods: We applied the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR). SO was verified by using dual-emission X-ray absorptiometry. Results: We found five women with SO. Women had higher body fat and lower muscle mass compared with men. There was a significant relationship between body fat and cognitive performance only in men (r=0.65; p<0.01) adjusted by age and education. Men with obesity and aged >75 years had better cognitive performance compared with non-obese men aged <75 years (p=0.010) and women with obesity aged >75 years (p=0.033). Conclusions: Women with AD had higher body fat and lower muscle mass than men. SO occurs in older women with AD. Men with higher body fat showed better cognitive performance, independent of age and education. RESUMO. A obesidade sarcopênica (SO), coocorrência de sarcopenia e obesidade, está associada à perda funcional, à fragilidade e à incapacidade em idosos. Recentemente, verificou-se que a SO está associada ao desempenho cognitivo reduzido em adultos. No entanto, não foram feitos estudos de SO em idosos com doença de Alzheimer (AD). Objetivo: Verificar a ocorrência de obesidade sarcopênica e fatores associados em 43 adultos idosos com doença de Alzheimer. Métodos: Aplicamos o miniexame do estado mental (MEEM) e a avaliação clínica da demência (CDR). A SO foi verificada utilizando a absorciometria de dupla emissão de raios X. Resultados: Foram classificadas cinco idosas com SO. As mulheres idosas tinham maior gordura corporal e menor massa muscular em comparação com os homens. Houve relação significativa, ajustada por idade e educação, entre gordura corporal e desempenho cognitivo apenas nos homens (r=0,65; p<0,01). Os homens com obesidade e com mais de 75 anos tiveram melhor desempenho cognitivo em comparação com os homens não obesos <75 anos (p=0,010) e com as mulheres com obesidade >75 anos (p=0,033). Conclusões: As mulheres com AD tinham maior gordura corporal e menor massa muscular do que os homens. A SO ocorreu em mulheres mais velhas com AD. Os homens com maior gordura corporal apresentaram melhor desempenho cognitivo, independentemente da idade e da educação.
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Disclosure: The authors report no conflicts of interest.
Authors’ contributions. TGC: conceptualization, data curation, formal analysis, and writing – review & editing. CVC: conceptualization, data curation, investigation, and roles/writing – original draft. CM: conceptualization, supervision, formal analysis, project administration, and writing – review & editing. DFS: formal analysis, roles/writing – original draft, and writing – review & editing. JMSV: conceptualization, data curation, investigation, and roles/writing – original draft. ERV: formal analysis and writing – review & editing. WCFNS: supervision, formal analysis, and writing – review & editing. JSB: project administration, resources, supervision, formal analysis, and writing – review & editing.
ISSN:1980-5764
1980-5764
DOI:10.1590/1980-5764-dn-2021-0039