RANTES chemokine expression in cell-mediated transplant rejection of the kidney

RANTES (regulated upon activation, normal T cell expressed and secreted) is a chemotactic cytokine (a chemokine) for memory T lymphocytes, monocytes, and eosinophils. RANTES expression was studied in renal allograft biopsy specimens. Although RANTES was not expressed in samples taken one hour after...

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Published inThe Lancet (British edition) Vol. 343; no. 8891; pp. 209 - 211
Main Authors Pattison, J.M., Nelson, P.J., von Leuttichau, I., Krensky, A.M., Huie, P., Farshid, G., Sibley, R.K.
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 22.01.1994
Lancet
Elsevier Limited
Subjects
Biological and medical sciences
Biopsy
Chemokine CCL5
Chemotaxis - immunology
Cyclosporine - adverse effects
Endothelium, Vascular - chemistry
Epithelium - chemistry
Gene Expression
Graft Rejection - genetics
Graft Rejection - immunology
Graft Rejection - pathology
Humans
Immunity, Cellular
In Situ Hybridization
Investigative techniques, diagnostic techniques (general aspects)
Kidney Transplantation
Kidney Tubules - blood supply
Kidney Tubules - cytology
Kidneys
Leukocytes, Mononuclear - chemistry
Lymphocytes
Lymphokines - analysis
Lymphokines - genetics
Lymphokines - immunology
Medical research
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Proteins
Ribonucleic acid
RNA
RNA, Messenger - analysis
RNA, Messenger - genetics
Transplants & implants
Urinary system
Human
Pathology
Urinary system disease
Treatment
Immunological investigation
Surgery
Cytokine
T-Lymphocyte
Exploration
Molecular biology
Homotransplantation
Kidney
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Summary:RANTES (regulated upon activation, normal T cell expressed and secreted) is a chemotactic cytokine (a chemokine) for memory T lymphocytes, monocytes, and eosinophils. RANTES expression was studied in renal allograft biopsy specimens. Although RANTES was not expressed in samples taken one hour after transplantation, or in native renal biopsy specimens from patients with cyclosporin nephrotoxicity, it was expressed during cell-mediated transplant rejection. RANTES mRNA was detected in infiltrating mononuclear cells and renal tubular epithelium, and RANTES protein was localised to mononuclear cells, tubular epithelium, and vascular endothelium. This suggests RANTES has a role in allograft rejection.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)90992-X