An immunoendocrinological hypothesis of HIV infection

The effect of glucocorticoid production on HIV infection and the role of cytokines in the disease are explored. A possible therapeutic strategy involving the control of the cortisol/dehydroepiandrotestosterone sulfate ratio to reduce overproduction of type-2 cytokines is suggested.

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 343; no. 8912; pp. 1552 - 1553
Main Authors Clerici, M, Villa, M.L, Bevilacqua, M, Vago, T, Norbiato, G, Shearer, G.M
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 18.06.1994
Lancet
Elsevier Limited
Subjects
Adrenal glands
AIDS/HIV
Antibody Formation
Biological and medical sciences
Cell Death - immunology
Cytokines - biosynthesis
Dehydroepiandrosterone - metabolism
Endocrine system
Glucocorticoids - biosynthesis
Glucocorticoids - therapeutic use
HIV
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - metabolism
Human immunodeficiency virus
Humans
Hydrocortisone - biosynthesis
Hydrocortisone - therapeutic use
Immunity (Disease)
Immunity, Cellular
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Medical sciences
Steroids
T-Lymphocytes - immunology
Infection
Human
Immunopathology
Pathophysiology
Viral disease
AIDS
Glucocorticoid
Immune deficiency
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Summary:The effect of glucocorticoid production on HIV infection and the role of cytokines in the disease are explored. A possible therapeutic strategy involving the control of the cortisol/dehydroepiandrotestosterone sulfate ratio to reduce overproduction of type-2 cytokines is suggested.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)92944-0