Cardiac Conduction Disorders Due to Acquired or Genetic Causes in Young Adults: A Review of the Current Literature

• Published in: Journal of the American Heart Association Vol. 14; no. 9; p. e040274
• Main Authors: Balla, Cristina, Canovi, Luca, Zuin, Marco, Di Lenno, Luca, Berloni, Maria L., de Carolis, Beatrice, Di Domenico, Assunta, Tonet, Elisabetta, Vitali, Francesco, Malagu, Michele, Boriani, Giuseppe, Bertini, Matteo
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 06.05.2025; Wiley
• Subjects: Adult; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - genetics; Arrhythmias, Cardiac - physiopathology; Arrhythmias, Cardiac - therapy; atrioventricular block; cardiac conduction disorders; Cardiac Conduction System Disease - diagnosis; Cardiac Conduction System Disease - etiology; Cardiac Conduction System Disease - genetics; Cardiac Conduction System Disease - physiopathology; Cardiac Conduction System Disease - therapy; Contemporary Review; Electrocardiography; genetic; Genetic Predisposition to Disease; Heart Conduction System - physiopathology; Humans; myocardial disease; Risk Factors; Young Adult; young adults; genetic; cardiac conduction disorders; myocardial disease; atrioventricular block; young adults
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.124.040274

Cardiac conduction disorders can manifest in young adults in isolated forms, associated with myocardial diseases or as part of a multiorgan disorder. Underlying causes of cardiac conduction disorders may be genetically determined or acquired. Cardiac conduction disorder in young adults is a complex and often underestimated and underrecognized disease that may need of a multidisciplinary team for the diagnosis, treatment, and long‐term management of these patients. Therefore, it is crucial to raise clinicians' awareness of this condition. In this review, we provide a comprehensive update on the cause, diagnosis, and treatment of young adults with cardiac conduction disorders, also suggesting potential strategies to improve the current clinical management of these patients.