Effects of Alcohol and Menstrual Cycle on Insulin-like Growth Factor-I and Insulin-like Growth Factor Binding Protein-3
Alcohol ingestion and insulin-like growth factor-I (IGF-I) have been associated with increased breast cancer risk, the latter primarily in premenopausal women. We investigated whether alcohol ingestion altered IGF-I or its major binding protein (BP), IGFBP-3, in a controlled feeding study in premeno...
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Published in | Cancer epidemiology, biomarkers & prevention Vol. 13; no. 12; pp. 2264 - 2267 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Association for Cancer Research
01.12.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Alcohol ingestion and insulin-like growth factor-I (IGF-I) have been associated with increased breast cancer risk, the latter
primarily in premenopausal women. We investigated whether alcohol ingestion altered IGF-I or its major binding protein (BP),
IGFBP-3, in a controlled feeding study in premenopausal women. We also determined whether IGF-I or IGFBP-3 was affected by
menstrual cycle phase. Serum was collected from 31 individuals who were randomly assigned to consume either 0 or 30 g (two
drinks) of alcohol daily for three menstrual cycles and who then crossed over to the other alcohol level for three cycles.
All calories were provided and weight was maintained during the study. For both alcohol levels, serum was collected during
the final cycle at early follicular, periovulatory, and luteal phases. Relative to the follicular phase, IGF-I levels increased
by 3.3% and 7.6% in the periovulatory and luteal phases, respectively ( P for trend = 0.004). Although alcohol ingestion did not affect this increase, it significantly reduced IGF-I concentrations
at all phases (9.5%; P < 0.001), whereas IGFBP-3 was unaffected by either menstrual phase or alcohol. This is the first controlled diet study to
show that alcohol decreases serum IGF-I in premenopausal women and that IGF-I significantly increases over the course of the
menstrual cycle whether or not alcohol is present. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-3 |
ISSN: | 1055-9965 1538-7755 |
DOI: | 10.1158/1055-9965.2264.13.12 |