Effects of Acute Administration of Transdermal Estrogen on Postmenopausal Women With Systemic Hypertension

• Published in: The American journal of cardiology Vol. 80; no. 5; pp. 652 - 655
• Main Authors: Mercuro, Giuseppe, Zoncu, Sandra, Pilia, Isa, Lao, Adriana, Benedetto Melis, Gian, Cherchi, Angelo
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1997; Elsevier; Elsevier Limited
• Subjects: Administration, Cutaneous; Biological and medical sciences; Blood pressure; Blood Pressure - drug effects; Blood Pressure Determination; Cross-Over Studies; Double-Blind Method; Drugs; Estradiol - administration & dosage; Estradiol - pharmacology; Female; Hormones. Endocrine system; Humans; Hypertension; Hypertension - physiopathology; Medical research; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Postmenopause; Women; Human; Hypertension; Acute; Menopause; Sex; 17β-Estradiol; Cardiovascular disease; Catecholamine; Blood plasma; Percutaneous route; Chemotherapy; Treatment; Female; Arterial pressure; Norepinephrine; Ambulatory; Sex steroid hormone; Monitoring
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/S0002-9149(97)00444-X

We studied 16 postmenopausal women with mild to moderate hypertension according to a randomized, double-blind protocol. They received patches of transdermal estradiol-17beta rated to deliver 100 mg/day of substance or matched placebo. A 24-hour ambulatory blood pressure (BP) monitoring was performed at baseline and after drug administrations. Our data show that estradiol-17beta exerts beneficial effects, both in lowering elevated BP levels and in maintaining a uniform BP control over 24 hours. Estrogen replacement therapy could be considered when significant changes in BP occur during the postmenopausal period.