TISIDB: an integrated repository portal for tumor–immune system interactions
Abstract Summary The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data...
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| Published in | Bioinformatics Vol. 35; no. 20; pp. 4200 - 4202 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
15.10.2019
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| Online Access | Get full text |
| ISSN | 1367-4803 1367-4811 1460-2059 1367-4811 |
| DOI | 10.1093/bioinformatics/btz210 |
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| Abstract | Abstract
Summary
The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.
Availability and implementation
http://cis.hku.hk/TISIDB
Supplementary information
Supplementary data are available at Bioinformatics online. |
|---|---|
| AbstractList | Abstract
Summary
The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.
Availability and implementation
http://cis.hku.hk/TISIDB
Supplementary information
Supplementary data are available at Bioinformatics online. The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.SUMMARYThe interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication.http://cis.hku.hk/TISIDB.AVAILABILITY AND IMPLEMENTATIONhttp://cis.hku.hk/TISIDB.Supplementary data are available at Bioinformatics online.SUPPLEMENTARY INFORMATIONSupplementary data are available at Bioinformatics online. The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor-immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. http://cis.hku.hk/TISIDB. Supplementary data are available at Bioinformatics online. |
| Author | Wong, Ching Ngar Chan, Nam Wai Wu, Wai Chung Wong, Choi Yiu Tong, Yin Zhang, Jiangwen Chu, Ka Chi Chen, Ian Zhong, Jia Yi Lau, Chit Ying Ru, Beibei Zhong, Sophia Shek Wa |
| Author_xml | – sequence: 1 givenname: Beibei surname: Ru fullname: Ru, Beibei organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 2 givenname: Ching Ngar surname: Wong fullname: Wong, Ching Ngar organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 3 givenname: Yin surname: Tong fullname: Tong, Yin organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 4 givenname: Jia Yi surname: Zhong fullname: Zhong, Jia Yi organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 5 givenname: Sophia Shek Wa surname: Zhong fullname: Zhong, Sophia Shek Wa organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 6 givenname: Wai Chung surname: Wu fullname: Wu, Wai Chung organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 7 givenname: Ka Chi surname: Chu fullname: Chu, Ka Chi organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 8 givenname: Choi Yiu surname: Wong fullname: Wong, Choi Yiu organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 9 givenname: Chit Ying surname: Lau fullname: Lau, Chit Ying organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 10 givenname: Ian surname: Chen fullname: Chen, Ian organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 11 givenname: Nam Wai surname: Chan fullname: Chan, Nam Wai organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China – sequence: 12 givenname: Jiangwen orcidid: 0000-0002-2911-8446 surname: Zhang fullname: Zhang, Jiangwen email: jzhang1@hku.hk organization: School of Biological Sciences, The University of Hong Kong, Hong Kong, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30903160$$D View this record in MEDLINE/PubMed |
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The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate... The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive... |
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