TISIDB: an integrated repository portal for tumor–immune system interactions

• Published in: Bioinformatics Vol. 35; no. 20; pp. 4200 - 4202
• Main Authors: Ru, Beibei, Wong, Ching Ngar, Tong, Yin, Zhong, Jia Yi, Zhong, Sophia Shek Wa, Wu, Wai Chung, Chu, Ka Chi, Wong, Choi Yiu, Lau, Chit Ying, Chen, Ian, Chan, Nam Wai, Zhang, Jiangwen
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 15.10.2019
• ISSN: 1367-4803; 1367-4811; 1460-2059; 1367-4811
• DOI: 10.1093/bioinformatics/btz210

Abstract Summary The interaction between tumor and immune system plays a crucial role in both cancer development and treatment response. To facilitate comprehensive investigation of tumor–immune interactions, we have designed a user-friendly web portal TISIDB, which integrated multiple types of data resources in oncoimmunology. First, we manually curated 4176 records from 2530 publications, which reported 988 genes related to anti-tumor immunity. Second, genes associated with the resistance or sensitivity of tumor cells to T cell-mediated killing and immunotherapy were identified by analyzing high-throughput screening and genomic profiling data. Third, associations between any gene and immune features, such as lymphocytes, immunomodulators and chemokines, were pre-calculated for 30 TCGA cancer types. In TISIDB, biologists can cross-check a gene of interest about its role in tumor–immune interactions through literature mining and high-throughput data analysis, and generate testable hypotheses and high quality figures for publication. Availability and implementation http://cis.hku.hk/TISIDB Supplementary information Supplementary data are available at Bioinformatics online.