Orbital Involvement in Multiple Myeloma: First Sign of Insufficient Chemotherapy

Orbital involvement in multiple myeloma is unusual. We describe the case of a 60-year-old male who presented with left proptosis, reduced visual acuity, diplopia and progressing signs of globe indentation 2 months after chemotherapy for multiple myeloma. MRI showed a well-defined tumor filling the m...

Full description

Saved in:
Bibliographic Details
Published inOphthalmologica (Basel) Vol. 217; no. 1; pp. 76 - 78
Main Authors Kottler, Ulrike B., Cursiefen, Claus, Holbach, Leonard M.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland Karger 01.01.2003
S. Karger AG
Subjects
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Biomarkers, Tumor - metabolism
Case Report
Diplopia - diagnosis
Exophthalmos - diagnosis
Hematologic and hematopoietic diseases
Humans
Immunohistochemistry
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - pathology
Multiple Myeloma - radiotherapy
Orbital Neoplasms - drug therapy
Orbital Neoplasms - pathology
Orbital Neoplasms - radiotherapy
Treatment Failure
Vision Disorders - diagnosis
Visual Acuity
Immunohistochemistry
Chemotherapy
Orbital tumor
Clinicopathologic correlation
Multiple myeloma
Human
Immunopathology
Orbit(eye) disease
Malignant hemopathy
Myeloma
Case study
Pathology
Eye disease
Treatment
Immunoglobulinopathy
Lymphoproliferative syndrome
Online AccessGet full text

Cover

More Information
Summary:Orbital involvement in multiple myeloma is unusual. We describe the case of a 60-year-old male who presented with left proptosis, reduced visual acuity, diplopia and progressing signs of globe indentation 2 months after chemotherapy for multiple myeloma. MRI showed a well-defined tumor filling the mediobasal part of the left orbit. Incisional biopsy and reduction of tumor mass were performed using an anterior transconjunctival orbitotomy. Histopathologic findings and further systemic examination confirmed the reactivation of the multiple myeloma. Proptosis, intraocular pressure and visual acuity improved following external beam radiation therapy of the left orbit and repeated systemic chemotherapy. Orbital involvement in multiple myeloma was the only sign of insufficient chemotherapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Case Study-2
ObjectType-Feature-4
ObjectType-Report-1
ObjectType-Article-3
ISSN:0030-3755
1423-0267
DOI:10.1159/000068251