Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy

Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immedia...

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Bibliographic Details
Published inOphthalmology (Rochester, Minn.) Vol. 96; no. 7; p. 1048
Main Authors Guy, J R, Fagien, S, Donovan, J P, Rubin, M L
Format Journal Article
LanguageEnglish
Published United States 01.07.1989
Subjects
Adult
Female
Graves Disease - drug therapy
Humans
Hydrochlorothiazide - administration & dosage
Hypertension - drug therapy
Injections, Intravenous
Magnetic Resonance Imaging
Male
Methylprednisolone - therapeutic use
Middle Aged
Orbit - radiation effects
Tomography, X-Ray Computed
Visual Acuity
Visual Fields
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Summary:Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.
ISSN:0161-6420
DOI:10.1016/S0161-6420(89)32784-9